Titre du document / Document title

EFFICACY OF INGAVIRIN IN ADULTS WITH INFLUENZA

Auteur(s) / Author(s)

KOLOBUKHINA L. V. ; MERKULOVA L. N. ; SCHELKANOV M. Yu. ; BURTSEVA E. I. ; ISAEVA E. I. ; MALYSHEV N. A. ; LVOV D. K. ;

Résumé / Abstract

Aim. To compare therapeutic efficacy and safety of ingavirin and arbidol in patients with influenza. Material and methods. The trial included 105 patients with a verified diagnosis of influenza, definite clinical symptoms, body temperature at least 38°C and duration of the disease 36 hours maximum. Ingavirin efficacy was analysed basing on the evidence for 100 patients with uncomplicated influenza. The patients were randomized into three groups: taking ingavirin in a single daily dose 90 mg (n = 33), placebo (n = 36) or arbidol (200 mg 4 times a day). The duration of the treatment was 5 days. Results. Intake of ingavirin in initial 24-36 hours of the disease significantly reduced fever compared to placebo and arbidol (34.5, 72.0 and 48.4 hours, respectively). Ingaverin was less toxic and had no side effects. Conclusion. Ingaverin is safe and effective in the treatment of influenza. By some criteria it is more effective than arbidol.

Revue / Journal Title

Terapevtičeskij arhiv   ISSN 0040-3660 

Source / Source

2009, vol. 81, n^o3, pp. 51-54 [4 page(s) (article)]

Langue / Language

Russe

Editeur / Publisher

Medicina, Moskva, RUSSIE, FEDERATION DE  (1923) (Revue)

Mots-clés d'auteur / Author Keywords

influenza ; ingavirin ; arbidol ; treatment efficacy ;

Localisation / Location

INIST-CNRS, Cote INIST : 7283, 35400018617531.0120