Titre du document / Document title
Quinoxaline chemistry. Part 8. 2-[anilino]-3-[carboxy]-6(7)-substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity
Auteur(s) / Author(s)
LORIGA M. (1) ;
MORO P. (1) ;
SANNA P. (1) ;
PAGLIETTI G. (1) ;
ZANETTI S. (2) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Istituto di Chimica Farmaceutica, Università di Sassari, Via Muroni 23/A, 07100 Sassari, ITALIE
(2) Istituto di Microbiologia e Virologia delta Facoltà di Medicina, Viale S. Pietro, 07100 Sassari, ITALIE
Résumé / Abstract
Thirty quinoxalines bearing a substituted anilino group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10
-5 and 10
-4 molar concentrations. Interesting selectivities were also recorded between 10
-8 and 10
-6 M for a few compounds. One single compound exhibited good activity against Candida Albicans
Revue / Journal Title
Il Farmaco
ISSN
0014-827X
Source / Source
1997, vol. 52, n
o8-9, pp. 531-537 (9 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Lausanne, SUISSE
(1989-2005)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 3341, 35400007819007.0040
Nº notice refdoc (ud4) : 2137306
