Titre du document / Document title

Oral acyclovir in prevention of herpes labialis: A randomized, double-blind, multi-centered clinical trial

Auteur(s) / Author(s)

RABORN G. W. ⁽¹⁾ ; MARTEL A. Y. ⁽²⁾ ; GRACE M. G. A. ⁽¹⁾ ; MCGAW W. T. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ University of Alberta, CANADA
⁽²⁾ Le Centre Hospital de l'Université Laval, CANADA

Résumé / Abstract

Objective. A three-center, randomized, double-blind, placebo-controlled acyclovir clinical trial was conducted among Canadian skiers over a 2-year period. Study Design. All patients enrolled in the study reported a history of recurrent herpes labialis with a greater-than-50% chance of a sun-induced trigger. There were 239 patients enrolled, and 237 of these were included in the analysis. For a minimum of 3 days and a maximum of 7 days, each patient received 800 mg of oral acyclovir twice daily (1600 mg/day) 12 to 24 hours before exposure to the sun. A minimum of 3 hours of outdoor activity was required each day. Results. No differences were detected in baseline and outcome measures among the centers, and results from all three centers were combined for further analysis. There was no difference in healing rate between the acyclovir and placebo groups for the first 4 days. Patients using acyclovir healed slightly faster on days 5 and 6, and nearly all patients in both the acyclovir and placebo groups were healed by day 7. Adverse events were evenly distributed; no withdrawals were required in either group. Conclusion. 800-mg oral acyclovir taken twice a day was not significantly better than a placebo either in effectiveness and prevention of recurrent herpes labialis or in adverse effects.

Revue / Journal Title

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics   ISSN 1079-2104 

Source / Source

1998, vol. 85, n^o1, pp. 55-59 (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, St. Louis, MO, ETATS-UNIS  (1995) (Revue)

Mots-clés anglais / English Keywords

Herpes ; Lip ; Prevention ; Recurrence ; Oral administration ; Aciclovir ; Chemoprophylaxis ; Exposure ; Sun ; Comparative study ; Placebo ; Controlled therapeutic trial ; Multicenter study ; Human ; Acyclic nucleoside ; Purine nucleoside ; Viral disease ; Infection ; Skin disease ;

Mots-clés français / French Keywords

Herpès ; Lèvre ; Prévention ; Récurrence ; Voie orale ; Aciclovir ; Chimioprophylaxie ; Exposition ; Soleil ; Etude comparative ; Placebo ; Essai thérapeutique contrôlé ; Etude multicentrique ; Homme ; Nucléoside acyclique ; Purine nucléoside ; Virose ; Infection ; Peau pathologie ;

Mots-clés espagnols / Spanish Keywords

Herpes ; Labio ; Prevención ; Recurrencia ; Vía oral ; Aciclovir ; Quimioprofilaxis ; Exposición ; Sol ; Estudio comparativo ; Placebo ; Ensayo terapéutico controlado ; Estudio multicéntrico ; Hombre ; Nucleósido acíclico ; Purina nucleósido ; Virosis ; Infección ; Piel patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 5101, 35400007826440.0100