RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Effects of a phytopreparation from Helleborus niger on immunocompetent cells in vitro

Auteur(s) / Author(s)

BÜSSING A. (1) ; SCHWEIZER K. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Krebsforschung Herdecke, Department of Applied Immunology, Communal Hospital Herdecke, Beckweg 4, 58313 Herdecke, ALLEMAGNE
(2) Institute of Medical Immunology, Technical University (RWTH), Aachen, ALLEMAGNE

Résumé / Abstract

Extracts of Helleborus species are used as phytopreparations with immunostimulatory properties in Romanian traditional medicine. In Germany, Helleborus niger is used in homeopathy and as an adjuvant therapy in the treatment of tumor patients in anthroposophical medicine. In vitro application of an aqueous extract from Helleborus niger resulted in a slight induction of sister chromatid exchanges (SCE) in cultured peripheral blood mononuclear cells (PBMC) from healthy individuals, an effect associated with a slight increase of the [3H]thymidine uptake in the DNA of isolated lymphocytes. Since the cytokines interleukin (IL)-2 and tumor necrosis factor (TNF)-α were reported to increase the number of SCE, we measured the concentrations of these cytokines in the supernatants of cultured PBMC treated with the plant extract. Here, no significant changes were observed as compared with the controls, but a trend to higher supernatant concentrations of TNF-α in six out of ten individuals was noted. Compared with lymphocytes treated with the alkylating substance, cyclophosphamide, the increase of the SCE levels induced by the plant extract is weak. The relevance of this DNA destabilizing property remains to be clarified.

Revue / Journal Title

Journal of ethnopharmacology    ISSN  0378-8741 

Source / Source

1998, vol. 59, no3, pp. 139-146 (1 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Shannon, IRLANDE  (1978) (Revue)

Mots-clés anglais / English Keywords

Plant origin

;

Helleborus niger

;

Extract

;

Whole plant

;

Medicinal plant

;

Folk medicine

;

Romania

;

Toxicity

;

Mutagen

;

Carcinogen

;

Mononuclear cell

;

Normal

;

Human

;

Sister chromatid exchange

;

In vitro

;

Immunomodulator

;

Pharmacognosy

;

Lymphocyte

;

Cell proliferation

;

Cytokine

;

Ranunculaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Europe

;

Mots-clés français / French Keywords

Origine végétale

;

Helleborus niger

;

Extrait

;

Plante entière

;

Plante médicinale

;

Médecine traditionnelle

;

Roumanie

;

Toxicité

;

Mutagène

;

Carcinogène

;

Mononucléaire

;

Normal

;

Homme

;

Echange chromatide soeur

;

In vitro

;

Immunomodulateur

;

Pharmacognosie

;

Lymphocyte

;

Multiplication cellulaire

;

Cytokine

;

Ranunculaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Europe

;

Mots-clés espagnols / Spanish Keywords

Origen vegetal

;

Helleborus niger

;

Extracto

;

Planta entera

;

Planta medicinal

;

Medicina tradicional

;

Rumania

;

Toxicidad

;

Mutágeno

;

Carcinógeno

;

Mononuclear

;

Normal

;

Hombre

;

Intercambio cromátide hermana

;

In vitro

;

Inmunomodulador

;

Farmacognosia

;

Linfocito

;

Multiplicación celular

;

Citoquina

;

Ranunculaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Europa

;

Localisation / Location

INIST-CNRS, Cote INIST : 18028, 35400007851638.0040

Nº notice refdoc (ud4) : 2132740



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas