Titre du document / Document title
Solubility study of tolbutamide in monocomponent and dicomponent solutions of water
Auteur(s) / Author(s)
VEIGA M. D.
(1) ;
AHSAN F.
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Departamento de Farmacia y Tecnologia Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Avda. Complutense s/n, 28040, Madrid, ESPAGNE
Résumé / Abstract
Solubility of tolbutamide was studied in different monocomponent (aqueous solutions of surfactant or <(-cyclodextrin) and dicomponent solutions (aqueous solutions of surfactant with β-cyclodextrin). Surfactants used were Tween 20 (Polysorbate 20), Brij 35 (Poloxyl 23 lauryl ether) and sodium lauryl sulphate. In dicomponent solutions, surfactant/β-cyclodextrin ratios were 1:1, 1:2. 1:3 mol/mol. Results of drug solubility from demineralised water and monocomponent solutions containing different surfactants in various concentrations were almost the same. even though most of the used concentrations were above the critical micelle concentrations of some of the surface active agents. Although tolbutamide/β-cyclodextrin inclusion compound was formed in the monocomponent solutions of β-cyclodextrin, however, the formation of an inclusion compound was impeded in the Brij 35/β-cyclodextrin and sodium lauryl sulphate/β-cyclodextrin dicomponent solutions. Data indicate that surfactants compete with drug molecules to form inclusion compounds with β-cyclodextrin and eventually modify the drug solubility. Results also demonstrate that the resultant competitive binding depends on the chemistry of surface active agents.
Revue / Journal Title
International journal of pharmaceutics
ISSN 0378-5173
CODEN IJPHDE
Source / Source
1998, vol. 160, n
o1, pp. 43-49 (14 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Amsterdam, PAYS-BAS
(1978)
(Revue)
Mots-clés anglais / English Keywords
Tolbutamide ;
Hypoglycemic agent ;
Pharmaceutical technology ;
Dosage form ;
Cyclodextrin ;
Inclusion compound ;
Oligosaccharide ;
Molecular interaction ;
Solubility ;
Surfactant ;
Sorbate polymer ;
Lauryl sulfate ;
Physicochemical properties ;
Sulfonylureas ;
Mots-clés français / French Keywords
Tolbutamide ;
Hypoglycémiant ;
Technologie pharmaceutique ;
Forme pharmaceutique ;
Cycloheptaamylose ;
Cyclodextrine ;
Composé inclusion ;
Oligoside ;
Interaction moléculaire ;
Solubilité ;
Agent surface ;
Sorbate polymère ;
Sulfate(lauryl) ;
Propriété physicochimique ;
Sulfonylurées ;
β-cyclodextrine ;
Mots-clés espagnols / Spanish Keywords
Tolbutamida ;
Hipoglicemiante ;
Tecnología farmacéutica ;
Forma farmacéutica ;
Ciclodextrina ;
Compuesto inclusión ;
Oligósido ;
Interacción molecular ;
Solubilidad ;
Agente superficie ;
Sorbato polímero ;
Lauril sulfato ;
Propiedad fisicoquímica ;
Sulfonilureas ;
Localisation / Location
INIST-CNRS, Cote INIST : 16510, 35400007828016.0050
Nº notice refdoc (ud4) : 2132603
