Titre du document / Document title

A comparison of omeprazole, lansoprazole and pantoprazole in the maintenance treatment of severe reflux oesophagitis

Auteur(s) / Author(s)

JASPERSEN D. ; DIEHL K.-L. ; SCHOEPPNER H. ; GEYER P. ; MARTENS E. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Department of Gastroenterology, Academic Hospital Fulda, ALLEMAGNE
Department of Internal Medicine, Henry Ford Hospital, 2799 West Grand Blvd., Detroit, MI 48202-2689, ETATS-UNIS

Résumé / Abstract

Background: Proton pump inhibitors are effective for the healing of oesophagitis. Standard doses of omeprazole, lansoprazole or pantoprazole are sufficient for healing in mild to moderate cases of oesophagitis. Aim: To compare the efficacy of double the standard doses of omeprazole, lansoprazole or pantoprazole for maintenance treatment of severe oesophagitis complicated by a stricture. Methods: Thirty-six patients with reflux oesophagitis and stricture confirmed by endoscopy were included in a prospective study comparing three maintenance therapies. In all cases weekly dilatation of the stenosis was performed and patients were treated with omeprazole 20 mg b.d. until healing of oesophagitis and dysphagia relief were achieved. Thirty participants responded to therapy and were then randomly assigned to 4 weeks of maintenance treatment with omeprazole (20 mg b.d.; n = 10), lansoprazole (30 mg b.d.; n = 10) or pantoprazole (40 mg b.d.; n = 10). Subsequently, endoscopies were performed-the endoscopists were blinded to the therapy assignment. The endpoints were defined as the absence of oesophagitis, oesophageal stricture and complaints. Results: After 4 weeks of treatment, the number of patients remaining in remission (no oesophagitis or stricture and no symptoms) was nine out of 10 (90%) in the omeprazole group, two out of 10 (20%) in the lansoprazole group (P < 0.01) and three out of 10 (30%) in the pantoprazole group (P < 0.01). Conclusions: In our study omeprazole was superior to either lansoprazole or pantoprazole in the maintenance treatment of complicated gastro-oesophageal reflux disease.

Revue / Journal Title

Alimentary pharmacology & therapeutics   ISSN 0269-2813 

Source / Source

1998, vol. 12, n^o1, pp. 49-52 (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

Omeprazole ; Lansoprazole ; Pantoprazole ; Gastroesophageal reflux ; Antiulcer agent ; Stenosis ; Esophagus ; Comparative study ; Human ; Chemotherapy ; Maintenance treatment ; Complication ; Treatment efficiency ; Antisecretory agent ; Enzyme inhibitor ; Relapse ; Benzimidazole derivatives ; H⁺/K⁺-exchanging ATPase ; Digestive diseases ; Esophageal disease ; Hydrolases ; Enzyme ;

Mots-clés français / French Keywords

Oméprazole ; Lansoprazole ; Pantoprazole ; Reflux gastrooesophagien ; Antiulcéreux ; Sténose ; Oesophage ; Etude comparative ; Homme ; Chimiothérapie ; Traitement entretien ; Complication ; Efficacité traitement ; Antisécrétoire ; Inhibiteur enzyme ; Récidive ; Benzimidazole dérivé ; H⁺/K⁺-exchanging ATPase ; Appareil digestif pathologie ; Oesophage pathologie ; Hydrolases ; Enzyme ;

Mots-clés espagnols / Spanish Keywords

Omeprazol ; Lansoprazol ; Pantoprazol ; Reflujo gastroesofágico ; Antiulceroso ; Estenosis ; Esófago ; Estudio comparativo ; Hombre ; Quimioterapia ; Tratamiento sostén ; Complicación ; Eficacia tratamiento ; Antisecretorio ; Inhibidor enzima ; Recaida ; Benzimidazol derivado ; H⁺/K⁺-exchanging ATPase ; Aparato digestivo patología ; Esófago patología ; Hydrolases ; Enzima ;

Localisation / Location

INIST-CNRS, Cote INIST : 21831, 35400007800809.0070