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Titre du document / Document title

Vitisin A suppresses LPS-induced NO production by inhibiting ERK, p38, and NF-KB activation in RAW 264.7 cells

Auteur(s) / Author(s)

MI JEONG SUNG (1) ; DAVAATSEREN Munkhtugs (1) ; KIM Won (2) ; SUNG KWANG PARK (2) ; KIM Soon-Hee (1) ; HAENG JEON HUR (1) ; MYUNG SUNNY KIM (1) ; KIM Young-Sup (3) ; DAE YOUNG KWON (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Food Convergence Research Division, Korea Food Research Institute, Songnam, Gyongki-do, COREE, REPUBLIQUE DE
(2) Renal Regeneration Laboratory, Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, COREE, REPUBLIQUE DE
(3) Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejn, COREE, REPUBLIQUE DE

Résumé / Abstract

Vitisin A, a resveratrol tetramer isolated from Vitis vinifera roots, exhibits antioxidative, anticancer, antiapoptotic, and anti-inflammatory effects. It also inhibits nitric oxide (NO) production. Here, we examined the mechanism by which vitisin A inhibits NO production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells. Vitisin A dose dependently inhibited LPS-induced NO production and inducible NO synthase (iNOS) expression. In contrast, the production of proinflammatory cytokines such as tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) was not altered by vitisin A. To investigate the signaling pathway for NO inhibition by vitisin A, we examined nuclear factor-KB (NF-KB) activation in the mitogen-activated protein kinase (MAPK) pathway, an inflammation-induced signal pathway in RAW 264.7 cells. Vitisin A inhibited LPS-induced extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 phosphorylation and suppressed LPS-induced NF-KB activation in RAW 264.7 cells. This suggests that vitisin A decreased NO production via downregulation of ERK1/2 and p38 and the NF-KB signal pathway in RAW 264.7 cells.

Revue / Journal Title

International immunopharmacology    ISSN  1567-5769 

Source / Source

2009, vol. 9, no3, pp. 319-323 [5 page(s) (article)] (33 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (2001) (Revue)

Mots-clés anglais / English Keywords

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Vitidaceae

;

Enzyme

;

Transferases

;

Vitis vinifera

;

Inflammation

;

Macrophage

;

In vitro

;

Activation

;

Transcription factor NFκB

;

Signal transduction

;

Extracellular signal-regulated protein kinase

;

Mitogen-activated protein kinase

;

Nitric oxide

;

Lipopolysaccharide

;

Mots-clés français / French Keywords

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Vitidaceae

;

Enzyme

;

Transferases

;

Vitis vinifera

;

Inflammation

;

Macrophage

;

In vitro

;

Activation

;

Facteur transcription NFκB

;

Transduction signal

;

Extracellular signal-regulated protein kinase

;

Mitogen-activated protein kinase

;

Monoxyde d'azote

;

Lipopolyoside

;

Mots-clés espagnols / Spanish Keywords

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Vitidaceae

;

Enzima

;

Transferases

;

Vitis vinifera

;

Inflamación

;

Macrófago

;

In vitro

;

Activación

;

Factor transcripción NFκB

;

Transducción señal

;

Extracellular signal-regulated protein kinase

;

Mitogen-activated protein kinase

;

Nitrógeno monóxido

;

Lipopoliósido

;

Mots-clés d'auteur / Author Keywords

Vitisin A

;

Nitric oxide

;

Mitogen-activated protein kinase (MAPK)

;

Nuclear factor-KB (NF-KB)

;

Macrophage

;

Inflammation

;

Localisation / Location

INIST-CNRS, Cote INIST : 27109, 35400018484759.0090

Nº notice refdoc (ud4) : 21253190



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