RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Toxicity of the pharmaceutical clotrimazole to marine microalgal communities

Auteur(s) / Author(s)

PORSBRING Tobias (1) ; BLANCK Hans (1) ; TJELLSTRÖM Henrik (1) ; BACKHAUS Thomas (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Plant and Environmental Sciences, University of Gothenburg, Box 461, 40530 Göteborg, SUEDE

Résumé / Abstract

Clotrimazole belongs to the group of 14a-demethylase inhibiting fungicides. It is widely used in human and veterinary medicine and has been identified as a priority pollutant for the marine environment. However, the toxicity of clotrimazole to marine primary producers is largely unknown. We therefore sampled natural microalgal communities (periphyton) and exposed them to concentration series of clotrimazole over 4 days. 50 pmol/L clotrimazole caused a concentration-dependent accumulation of C14α-methylated sterol precursors, which coincided with a decrease in algal-specific C14-desmethyl sterols. This indicates an inhibition of algal 14a-demethylases already at environmental concentrations. A clotrimazole concentration of 500 pmol/L reduced total sterol content to 64% of control level. Community chlorophyll a content was affected by clotrimazole in a bi-phasic manner with first reductions becoming visible at 500 pmol/L, along with indications of an altered cycling of photoprotective xanthophyll pigments. Concentrations of 10-100 nmol/L and higher caused large reductions in community growth, and changed community pigment profiles in a concentration-dependent monotonous manner. The study further indicated that diatoms use obtusifoliol as a natural substrate for 14α-demethylase, just as higher plants do but also utilize norlanosterol.

Revue / Journal Title

Aquatic toxicology    ISSN  0166-445X   CODEN AQTODG 

Source / Source

2009, vol. 91, no3, pp. 203-211 [9 page(s) (article)] (3/4 p.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1981) (Revue)

Mots-clés anglais / English Keywords

Heterokontophyta

;

Organic compounds

;

Bacillariophyta

;

Algae

;

Aquatic environment

;

Sterol

;

Ecotoxicology

;

Periphyton

;

Community

;

Marine environment

;

Clotrimazole

;

Drug

;

Toxicity

;

Mots-clés français / French Keywords

Heterokontophyta

;

Composé organique

;

Microalgue

;

Bacillariophyta

;

Algae

;

Milieu aquatique

;

Stérol

;

Ecotoxicologie

;

Périphyton

;

Communauté

;

Milieu marin

;

Clotrimazole

;

Médicament

;

Toxicité

;

Mots-clés espagnols / Spanish Keywords

Heterokontophyta

;

Compuesto orgánico

;

Bacillariophyta

;

Algae

;

Medio acuático

;

Esterol

;

Ecotoxicología

;

Perifiton

;

Comunidad

;

Medio marino

;

Clotrimazol

;

Medicamento

;

Toxicidad

;

Mots-clés d'auteur / Author Keywords

Clotrimazole

;

Periphyton

;

Community ecotoxicology

;

Pharmaceuticals

;

Sterols

;

Diatoms

;

Norlanosterol

;

Localisation / Location

INIST-CNRS, Cote INIST : 18841, 35400018422486.0020

Nº notice refdoc (ud4) : 21146400



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas