Titre du document / Document title
Acasiane A and B and Farnesirane A and B, Diterpene Derivatives From the Roots of Acacia farnesiana
Auteur(s) / Author(s)
LIN An-Shen (1) ;
LIN Chia-Rong (1) ;
DU Ying-Chi (1) ;
LÜBKEN Tilo (1) ;
CHIANG Michael Y. (2) ;
CHEN I.-Hsiao (1) ;
WU Chin-Chung (1) ;
HWANG Tsong-Long (3) ;
CHEN Shu-Li (1) ;
YEN Ming-Hong (1) ;
CHANG Fang-Rong (1 4) ;
WU Yang-Chang (1 4 5) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, TAIWAN, PROVINCE DE CHINE
(2) Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, TAIWAN, PROVINCE DE CHINE
(3) Graduate Institute of Natural Products, Chang Gung University, Taoyuan, TAIWAN, PROVINCE DE CHINE
(4) Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, TAIWAN, PROVINCE DE CHINE
(5) National Sun Yat-Sen University-Kaohsiung Medical University joint Research Center, Kaohsiung, TAIWAN, PROVINCE DE CHINE
Résumé / Abstract
Four new diterpenes, acasiane A (1), acasiane B (2), farnesirane A (3), and farnesirane B (4), along with three known diterpenes (5-7), two triterpenes (8 and 9), and eight flavonoids (10-17) were isolated from the roots of Acacia farnesiana. The structures and relative configurations of these compounds were determined by various spectroscopic and x-ray analyses. All isolated compounds were evaluated for their in vitro cytotoxic activities against six human cancer cell lines (Hep G2, Hep 3B, MDA-MB-231, MCF-7, A549, and Ca9-22) with the MTT method. Betulinic acid (8) displayed moderate cytotoxicity (1.70-5.74μg/mL) towards five human cancer cell lines and the flavonoids had slight effects. In addition, 8, diosmetin (13), and 3',4',5-trihydroxy-7-methoxyflavone (15) slightly inhibited superoxide anion generation or elastase release by human neutrophils, indicating moderate anti-inflammatory activities.
Revue / Journal Title
Planta medica
ISSN
0032-0943
CODEN PLMEAA
Source / Source
2009, vol. 75, n
o3, pp. 256-261 [6 page(s) (article)] (18 ref.)
Langue / Language
Anglais
Editeur / Publisher
Thieme, Stuttgart, ALLEMAGNE
(1953)
(Revue)
Mots-clés anglais / English Keywords
Spermatophyta ;
Angiospermae ;
Dicotyledones ;
Leguminosae ;
Essential oil plant ;
Triterpene ;
Below ground plant part ;
Terpenoid ;
Plant origin ;
Medicinal plant ;
Pharmacognosy ;
Antiinflammatory agent ;
Cytotoxicity ;
Root ;
Diterpene ;
Mots-clés français / French Keywords
Spermatophyta ;
Angiospermae ;
Dicotyledones ;
Leguminosae ;
Plante à huiles essentielles ;
Lupane dérivé ;
Bétulinique acide ;
Cassane dérivé ;
Acacia farnesiana ;
Triterpène ;
Partie souterraine végétal ;
Terpénoïde ;
Origine végétale ;
Plante médicinale ;
Pharmacognosie ;
Antiinflammatoire ;
Cytotoxicité ;
Racine ;
Diterpène ;
Mots-clés espagnols / Spanish Keywords
Spermatophyta ;
Angiospermae ;
Dicotyledones ;
Leguminosae ;
Planta de aceites esenciales ;
Triterpeno ;
Parte subterránea vegetal ;
Terpenoide ;
Origen vegetal ;
Planta medicinal ;
Farmacognosia ;
Antiinflamatorio ;
Citotoxicidad ;
Raíz ;
Diterpeno ;
Mots-clés d'auteur / Author Keywords
Mimosoideae ;
Acacia farnesiana ;
cassane diterpene ;
betulinic acid ;
cytotoxicity ;
anti-inflammatory ;
Localisation / Location
INIST-CNRS, Cote INIST : 9624, 35400018417775.0110
Nº notice refdoc (ud4) : 21100860
