Titre du document / Document title

Acyclovir use and survival among human immunodeficiency virus-infected patients with CD4 cell counts of <500/mm³

Auteur(s) / Author(s)

Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA)
TORRES R. A. ; NEATON J. D. ; WENTWORTH D. N. ; BARR M. R. ; ABRAMS D. ; SHERER R. ; WARD T. ; SAMPSON J. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

AIDS Center, St. Vincent's Hospital and Medical Center of New York, New York, ETATS-UNIS
Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, Minnesota, ETATS-UNIS
Community Consortium, San Francisco General Hospital, San Francisco, California, ETATS-UNIS
HIV Primary Care Center, Cook County Hospital, Chicago, Illinois, ETATS-UNIS
The Research and Education Group, Portland, Oregon, ETATS-UNIS

Résumé / Abstract

To examine the relationship between acyclovir use and survival in AIDS, we performed a retrospective analysis of data collected through an observational cohort of the 17-site Community Program for Clinical Research on AIDS (CPCRA), under the sponsorship of the National Institute of Allergy and Infectious Diseases. Data were analyzed regarding 2,368 patients with CD4⁺ lymphocyte counts of <500/mm³, and 7,836 follow-up visits were conducted from September 1990 to July 1994. Factors associated with use of acyclovir were studied by stratified analysis of variance and Mantel-Haenzel X² tests. The association between acyclovir and survival was studied with use of the proportional hazards regression model. Individuals reporting acyclovir use were more likely to be white, male, and homosexual; to have a history of herpes simplex and zoster; and to have lower CD4⁺ T cell counts than those who did not. After adjustments for differences in baseline factors, acyclovir use was not associated with prolonged survival.

Revue / Journal Title

Clinical infectious diseases   ISSN 1058-4838   CODEN CIDIEL 

Source / Source

1998, vol. 26, n^o1, pp. 85-90 (12 ref.)

Langue / Language

Anglais

Editeur / Publisher

University of Chicago Press, Chicago, IL, ETATS-UNIS  (1992) (Revue)

Mots-clés anglais / English Keywords

AIDS ; Chemotherapy ; Treatment ; Evolution ; Treatment efficiency ; Prognosis ; Antiviral ; Survival ; Human ; Aciclovir ; Acyclic nucleoside ; Purine nucleoside ; Viral disease ; Infection ; Immunopathology ; Immune deficiency ;

Mots-clés français / French Keywords

SIDA ; Chimiothérapie ; Traitement ; Evolution ; Efficacité traitement ; Pronostic ; Antiviral ; Survie ; Homme ; Aciclovir ; Nucléoside acyclique ; Purine nucléoside ; Virose ; Infection ; Immunopathologie ; Immunodéficit ;

Mots-clés espagnols / Spanish Keywords

SIDA ; Quimioterapia ; Tratamiento ; Evolución ; Eficacia tratamiento ; Pronóstico ; Antiviral ; Sobrevivencia ; Hombre ; Aciclovir ; Nucleósido acíclico ; Purina nucleósido ; Virosis ; Infección ; Inmunopatología ; Inmunodeficiencia ;

Localisation / Location

INIST-CNRS, Cote INIST : 18407, 35400007741003.0120