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Titre du document / Document title

Pathophysiology and treatment of single-vessel coronary artery disease

Auteur(s) / Author(s)

GERSH B. J. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Division of Cardiology, Georgetown University Medical Center, Washington, DC, ETATS-UNIS

Résumé / Abstract

The optimal treatment of patients with single-vessel coronary artery disease (CAD) and chronic stable angina is controversial. Therapeutic options include medical therapy with pharmacologic agents and/or coronary revascularization via surgery (coronary artery bypass grafting [CABG]), percutaneous transluminal coronary angioplasty (PTCA), and/or other transcatheter techniques. Early studies found no difference in survival between medical and surgical treatment of patients with single-vessel disease and chronic stable angina. Although PTCA has been shown to improve symptoms and quality of life in patients with single-vessel disease and severe symptoms, improvement in survival and prevention of uture events are not established and multiple PTCA procedures or subsequent surgical treatment may be necessary. Medical therapy may be preferred in patients with mild or no symptoms. In patients with chronic stable angina, PTCA practice may not be consistent with current guidelines, particularly obtaining laboratory evidence of ischemia before the procedure. Stenoses that may lead to future coronary events cannot be accurately identified by angiography without evidence of ischemia or symptoms. Currently available comparative studies of patients with CAD do not reflect the impact of stent procedures and aggressive lipid lowering. Therefore, diagnostic and treatment options should be individualized in patients with single-vessel disease and chronic stable angina, and additional randomized trials are necessary to determine the optimal management of these patients.

Revue / Journal Title

The American journal of cardiology    ISSN  0002-9149   CODEN AJCDAG 

Source / Source

Congrès
New Approaches to Cardiovascular Therapy. Symposium, Anaheim, California , ETATS-UNIS (15/03/1997)
1997, vol. 80, no 9A (44 p.)  (45 ref.), pp. 2I-10I

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1958) (Revue)

Mots-clés anglais / English Keywords

Coronary heart disease

;

Lesion

;

Single coronary artery

;

Instrumental dilatation

;

Bypass

;

Aortocoronary

;

Survival

;

Pathophysiology

;

Treatment

;

Prognosis

;

Human

;

Cardiovascular disease

;

Instrumentation therapy

;

Surgery

;

Mots-clés français / French Keywords

Cardiopathie coronaire

;

Lésion

;

Artère coronaire unique

;

Dilatation instrumentale

;

Dérivation

;

Aortocoronaire

;

Survie

;

Physiopathologie

;

Traitement

;

Pronostic

;

Homme

;

Appareil circulatoire pathologie

;

Traitement instrumental

;

Chirurgie

;

Mots-clés espagnols / Spanish Keywords

Cardiopatía coronaria

;

Lesión

;

Arteria coronaria única

;

Dilatación instrumental

;

Derivación

;

Aortocoronaria

;

Sobrevivencia

;

Fisiopatología

;

Tratamiento

;

Pronóstico

;

Hombre

;

Aparato circulatorio patología

;

Tratamiento instrumental

;

Cirugía

;

Localisation / Location

INIST-CNRS, Cote INIST : 8674, 35400007938492.0010

Nº notice refdoc (ud4) : 2089907



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