Titre du document / Document title

FASTING TOTAL HOMOCYSTEINE (tHcy) CONCENTRATION AND MORTALITY IN OLDER MEXICAN AMERICANS

Auteur(s) / Author(s)

COLON LOPEZ V. ⁽¹⁾ ; HAAN M. N. ⁽¹⁾ ; AIELLO A. E. ⁽¹⁾ ; GHOSH D. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ department of Epidemiology University of Michigan, School of Public Health, Ann Arbor, MI, ETATS-UNIS
⁽²⁾ department of Statistics Pennsylvania State University, ETATS-UNIS

Résumé / Abstract

Objectives: This study examines the association between tHcy on cardiovascular and non-cardiovascular mortality. Design: Longitudinal study of 1,633 Mexican Americans age >60 years recruited in 1998. Setting: Sacramento, California. Measurements: Cox proportional models were used to estimate the effects of tHcy on mortality rate in the total sample and in a subgroup of subjects without a history of cardiovascular disease at baseline. Results: About half of the cohort was born in Mexico. Among Mexican-born participants, high tHcy (>11.0μmol/L) was associated with a higher rate of cardiovascular mortality compared to those with low tHcy concentration ≤11.0μmol/L (HR=2.74 95%CI [1.61,4.66]). Among the US-born, higher tHcy predicted cardiovascular mortality (HR=1.74 95%CI [1.08, 2.82]). When the effects of tHcy were evaluated in the subgroup without self-report of cardiovascular disease at baseline, the effect of high tHcy on mortality remained only among the Mexican-born. These differences did not appear to be influenced by demographic, lifestyle factors, chronic diseases or biological markers at baseline. No significant associations between tHcy and non-cardiovascular mortality were observed for either group. Conclusions: The effect of tHcy on cardiovascular mortality is nearly 40% stronger among the immigrant group. tHcy might be an early marker of subclinical vascular pathology amongst the Mexican-born group, despite their apparently healthy profile at baseline.

Revue / Journal Title

The Journal of nutrition, health & aging   ISSN 1279-7707 

Source / Source

2008, vol. 12, n^o10, pp. 685-689 [5 page(s) (article)] (27 ref.)

Langue / Language

Anglais

Editeur / Publisher

Springer, Paris, FRANCE  (1997) (Revue)

Mots-clés anglais / English Keywords

Thiol ; Sulfur containing aminoacid ; Human ; America ; Central America ; Metabolic diseases ; Elderly ; Biological marker ; Nutrition ; Mexico ; Epidemiology ; Mortality ; Concentration ; Homocystein ; Fast ; Fasting ; Cardiovascular disease ;

Mots-clés français / French Keywords

Thiol ; Aminoacide soufré ; Homme ; Amérique ; Amérique Centrale ; Maladie métabolique ; Personne âgée ; Marqueur biologique ; Nutrition ; Mexique ; Epidémiologie ; Mortalité ; Concentration ; Homocystéine ; A jeun ; Jeûne alimentaire ; Pathologie de l'appareil circulatoire ;

Mots-clés espagnols / Spanish Keywords

Tiol ; Aminoácido azufrado ; Hombre ; America ; America central ; Metabolismo patología ; Anciano ; Marcador biológico ; Nutrición ; Méjico ; Epidemiología ; Mortalidad ; Concentración ; Homocisteína ; En ayunas ; Ayuno alimenticio ; Aparato circulatorio patología ;

Mots-clés d'auteur / Author Keywords

Homocysteine ; cardiovascular mortality ; mexican americans ; nutritional biomarkers ; elderly ;

Localisation / Location

INIST-CNRS, Cote INIST : 26862, 35400018396961.0010