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Titre du document / Document title

Potassium-magnesium citrate is an effective prophylaxis against recurrent calcium oxalate nephrolithiasis. Commentary

Auteur(s) / Author(s)

ETTINGER B. ; PAK C. Y. C. ; CITRON J. T. ; THOMAS C. ; ADAMS-HUET B. ; VANGESSEL A. ; PREMINGER G. M. (Commentateur) (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Division of Urology, Duke University Medical Center, Durham, North Carolina, ETATS-UNIS
Division of Research, Kaiser Permanente Medical Care Program, Oakland, California, ETATS-UNIS
Department of Mineral Metabolism, Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, ETATS-UNIS
Department of Medicine, Kaiser Permanente Medical Center, Walnut Creek, California, ETATS-UNIS
Department of Urology, Kaiser Permanente Medical Center, San Francisco, California, ETATS-UNIS
Kaiser Foundation Research Institute, Kaiser Foundation Hospitals, Oakland, California, ETATS-UNIS

Résumé / Abstract

Purpose: We examined the efficacy of potassium-magnesium citrate in preventing recurrent calcium oxalate kidney calculi. Materials and Methods: We conducted a prospective double-blind study of 64 patients who were randomly assigned to receive placebo or potassium-magnesium citrate (42 mEq. potassium, 21 mEq. magnesium, and 63 mEq. citrate) daily for up to 3 years. Results. New calculi formed in 63.6% of subjects receiving placebo and in 12.9% of subjects receiving potassium-magnesium citrate. When compared with placebo, the relative risk of treatment failure for potassium-magnesium citrate was 0.16 (95% confidence interval 0.05 to 0.46). potassium-magnesium citrate had a statistically significant effect (relative risk 0.10, 95% confidence interval 0.03 to 0.36) even after adjustment for possible confounders, including age, pretreatment calculous event rate and urinary biochemical abnormalities. Conclusions: Potassium-magnesium citrate effectively prevents recurrent calcium oxalate stones, and this treatment given for up to 3 years reduces risk of recurrence by 85%.

Revue / Journal Title

The Journal of urology    ISSN  0022-5347   CODEN JOURAA 

Source / Source

1997, vol. 158, no6, pp. 2069-2073 (14 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1917) (Revue)

Mots-clés anglais / English Keywords

Lithiasis

;

Kidney

;

Calcium complex

;

Oxalate

;

Potassium

;

Magnesium

;

Citrate

;

Treatment

;

Prevention

;

Human

;

Urinary system disease

;

Kidney disease

;

Urinary stone

;

Chemotherapy

;

Mots-clés français / French Keywords

Lithiase

;

Rein

;

Calcium complexe

;

Oxalate

;

Potassium

;

Magnésium

;

Citrate

;

Traitement

;

Prévention

;

Homme

;

Appareil urinaire pathologie

;

Rein pathologie

;

Calcul urinaire

;

Chimiothérapie

;

Mots-clés espagnols / Spanish Keywords

Litiasis

;

Riñón

;

Calcio complejo

;

Oxalato

;

Potasio

;

Magnesio

;

Citrato

;

Tratamiento

;

Prevención

;

Hombre

;

Aparato urinario patología

;

Riñón patología

;

Cálculo urinario

;

Quimioterapia

;

Localisation / Location

INIST-CNRS, Cote INIST : 2081, 35400007936884.0070

Nº notice refdoc (ud4) : 2068785



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