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Titre du document / Document title

Sleep loss results in an elevation of cortisol levels the next evening

Auteur(s) / Author(s)

LEPROULT R. (1) ; COPINSCHI G. (2) ; BUXTON O. (1) ; VAN CAUTER E. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Medicine, University of Chicago, Chicago, Illinois, ETATS-UNIS
(2) Center for the Study of Biological Rhythms and Laboratory of Experimental Medicine, Erasme Hospital, Université Libre de Bruxelles, Brussels, BELGIQUE

Résumé / Abstract

Sleep curtailment constitutes an increasingly common condition in industrialized societies and is thought to affect mood and performance rather than physiological functions. There is no evidence for prolonged or delayed effects of sleep loss on the hypothalamo-pituitary-adrenal (HPA) axis. We evaluated the effects of acute partial or total sleep deprivation on the nighttime and daytime profile of cortisol levels. Plasma cortisol profiles were determined during a 32-hour period (from 1800 hours on day I until 0200 hours on day 3) in normal young men submitted to three different protocols: normal sleep schedule (2300-0700 hours), partial sleep deprivation (0400-0800 hours), and total sleep deprivation. Alterations in cortisol levels could only be demonstrated in the evening following the night of sleep deprivation. After normal sleep, plasma cortisol levels over the 1800-2300hour period were similar on days I and 2. After partial and total sleep deprivation, plasma cortisol levels over the 1800-2300-hour period were higher on day 2 than on day 1 (37 and 45% increases, p = 0.03 and 0.003, respectively). and the onset of the quiescent period of cortisol secretion was delayed by at least I hour. We conclude that even partial acute sleep loss delays the recovery of the HPA from early morning circadian stimulation and is thus likely to involve an alteration in negative glucocorticoid feedback regulation. Sleep loss could thus affect the resiliency of the stress response and may accelerate the development of metabolic and cognitive consequences of glucocorticoid excess.

Revue / Journal Title

Sleep    ISSN  0161-8105   CODEN SLEED6 

Source / Source

1997, vol. 20, no10, pp. 865-870 (31 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Academy of Sleep Medicine, Darien, IL, ETATS-UNIS  (1978) (Revue)

Mots-clés anglais / English Keywords

Sleep

;

Deprivation

;

Hydrocortisone

;

Plasma

;

Stress

;

Emotion emotionality

;

Hypothalamohypophysoadrenal axis

;

Human

;

Glucocorticoid

;

Adrenal hormone

;

Affect affectivity

;

Mots-clés français / French Keywords

Sommeil

;

Privation

;

Hydrocortisone

;

Plasma

;

Stress

;

Emotion émotivité

;

Système hypothalamohypophysosurrénalien

;

Homme

;

Glucocorticoïde

;

Hormone surrénalienne

;

Affect affectivité

;

Mots-clés espagnols / Spanish Keywords

Sueño

;

Privación

;

Hidrocortisona

;

Plasma

;

Stress

;

Emoción emotividad

;

Sistema hipotalamohipofisosuprarrenal

;

Hombre

;

Glucocorticoide

;

Hormona suprarrenal

;

Afecto afectividad

;

Localisation / Location

INIST-CNRS, Cote INIST : 18084, 35400007966535.0060

Nº notice refdoc (ud4) : 2068517



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