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Titre du document / Document title

Repair of enamel by using hydroxyapatite nanoparticles as the building blocks

Auteur(s) / Author(s)

LI LI (1) ; HAIHUA PAN (1) ; JINHUI TAO (1) ; XURONG XU (1) ; CAIYUN MAO (2) ; XINHUA GU (2) ; RUIKANG TANG (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Centre of Biopathways and Biomaterials, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, CHINE
(2) First Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, Zhejiang 310003, CHINE

Résumé / Abstract

The application of calcium phosphates and their nanoparticles have been received great attention. However, hydroxyapatite (HAP) is not suggested in dental therapy to repair the damaged enamel directly although this compound has a similar chemical composition to enamel. We note that the size-effects of HAP are not taken into account in the previous studies as these artificial particles frequently have sizes of hundreds of nanometres. It has recently been revealed that the basic building blocks of enamel are 20-40 nm HAP nanoparticles. We suggest that the repair effect of HAP can be greatly improved if its dimensions can be reduced to the scale of the natural building blocks. Compared with conventional HAP and nano amorphous calcium phosphate (ACP), our in vitro experimental results demonstrate the advantages of 20 nm HAP in enamel repairs. The results of scanning electron microscopy, confocal laser scanning microscopy, quantitative measurement of the adsorption, dissolution kinetics, and nanoindentation, show the strong affinity, excellent biocompatibility, mechanical improvement, and the enhancement of erosion-free by using 20 nm particles as the repairing agent. However, these excellent in vitro repair effects cannot be observed when conventional HAP and ACP are applied. Clearly, nano HAP with a size of 20 nm shares similar characteristics to the natural building blocks of enamel so that it may be used as an effective repair material and anticaries agent. Our current study highlights the analogues of nano building blocks of biominerals during biomedical applications, which provide a novel pathway for biomimetic repair.

Revue / Journal Title

Journal of material chemistry    ISSN  0959-9428 

Source / Source

2008, vol. 18, no34, pp. 4079-4084 [6 page(s) (article)] (50 ref.)

Langue / Language

Anglais

Editeur / Publisher

Royal Society of Chemistry, Cambridge, ROYAUME-UNI  (1991) (Revue)

Mots-clés anglais / English Keywords

Biomimetics

;

Medical application

;

Erosion

;

Biocompatibility

;

Mechanical properties

;

Nanoindentation

;

Nanohardness

;

Dental application

;

Dental restoration

;

Kinetics

;

Dissolution

;

Adsorption

;

Confocal microscopy

;

Scanning electron microscopy

;

Tooth enamel

;

Particle size

;

Size effect

;

Chemical composition

;

Damage

;

Calcium phosphate

;

Nanostructured materials

;

Nanoparticles

;

Hydroxyapatite

;

Enamels

;

Mots-clés français / French Keywords

8783

;

6225

;

Biomimétique

;

Application médicale

;

Erosion

;

Biocompatibilité

;

Propriété mécanique

;

Nanoindentation

;

Nanodureté

;

Application dentaire

;

Dentisterie restauratrice

;

Cinétique

;

Dissolution

;

Adsorption

;

Microscopie confocale

;

Microscopie électronique balayage

;

Email dentaire

;

Dimension particule

;

Effet dimensionnel

;

Composition chimique

;

Endommagement

;

Phosphate de calcium

;

Nanomatériau

;

Nanoparticule

;

Apatite hydroxylée

;

Email

;

Mots-clés espagnols / Spanish Keywords

Aplicación medical

;

Biocompatibilidad

;

Nanoindentacion

;

Nanodureza

;

Aplicación dental

;

Restauración dental

;

Microscopía confocal

;

Esmalte dental

;

Calcio fosfato

;

Hidroxiapatito

;

Localisation / Location

INIST-CNRS, Cote INIST : 22603, 35400018524125.0120

Nº notice refdoc (ud4) : 20647239



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