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Titre du document / Document title

Daily Quercetin Supplementation Dose-Dependently Increases Plasma Quercetin Concentrations in Healthy Humans

Auteur(s) / Author(s)

EGERT Sarah (1) ; WOLFFRAM Siegfried (2) ; BOSY-WESTPHAL Anja (1) ; BOESCH-SAADATMANDI Christine (1) ; EVA WAGNER Anika (1) ; FRANK Jan (1) ; RIMBACH Gerald (1) ; MUELLER Manfred James (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Institute of Human Nutrition and Food Science, Physiology and Metabolism, Christian-Albrechts-University Kiel, 24105 Kiel, ALLEMAGNE
(2) Institute of Animal Nutrition, Physiology and Metabolism, Christian-Albrechts-University Kiel, 24105 Kiel, ALLEMAGNE

Résumé / Abstract

Our aim was to investigate the effects of an oral supplementation of quercetin at 3 different doses on plasma concentrations of quercetin, parameters of oxidant/antioxidant status, inflammation, and metabolism. To this end, 35 healthy volunteers were randomly assigned to take 50, 100, or 150 mg/d (group Q50-Q150) quercetin for 2 wk. Fasting blood samples were collected at the beginning and end of the supplementation period. Compared with baseline, quercetin supplementation significantly increased plasma concentrations of quercetin by 178% (Q50), 359% (Q100), and 570% (Q150; P< 0.01 for all). High interindividual variation was found for plasma quercetin concentrations (36-57%). Quercetin did not affect concentrations of serum uric acid or plasma α-and γ-tocopherols, oxidized LDL, and tumor necrosis factor-α, or plasma antioxidative capacity as assessed by the ferric-reducing antioxidant potential and oxygen radical absorbance capacity assays. In addition, serum lipids and lipoproteins, body composition, and resting energy expenditure did not significantly change during quercetin supplementation. Pharmacokinetics of quercetin were investigated in a subgroup of 15 volunteers. The areas under the plasma concentration-time curves ranged from 76.1 μmol·min·L-1 to 305.8 μmol·min·L-1 (50- and 150-mg dosages, respectively). Median maximum plasma concentrations of quercetin (431 nmol/L) were observed 360 min after intake of 150 mg quercetin. In conclusion, daily supplementation of healthy humans with graded concentrations of quercetin for 2 wk dose-dependently increased plasma quercetin concentrations but did not affect antioxidant status, oxidized LDL, inflammation, or metabolism.

Revue / Journal Title

The Journal of nutrition    ISSN  0022-3166   CODEN JONUAI 

Source / Source

2008, vol. 138, no9, pp. 1615-1621 [7 page(s) (article)] (51 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Society for Nutrition, Bethesda, MD, ETATS-UNIS  (1928) (Revue)

Mots-clés anglais / English Keywords

Micronutrient

;

Proanthocyanidin

;

Antioxidant

;

Biological fluid

;

Feeding

;

Polyphenol

;

Flavonoid

;

Human

;

Inflammation

;

Metabolism

;

Nutrition

;

Concentration

;

Blood plasma

;

Supplementation

;

Quercetin

;

Daily dose

;

Mots-clés français / French Keywords

Micronutriment

;

Proanthocyanidine

;

Antioxydant

;

Liquide biologique

;

Alimentation

;

Polyphénol

;

Flavonoïde

;

Flavonol dérivé

;

Homme

;

Inflammation

;

Métabolisme

;

Nutrition

;

Concentration

;

Plasma sanguin

;

Supplémentation

;

Quercétine

;

Dose journalière

;

Mots-clés espagnols / Spanish Keywords

Micronutriente

;

Proantocianidina

;

Antioxidante

;

Líquido biológico

;

Alimentación

;

Polifenol

;

Flavonoide

;

Hombre

;

Inflamación

;

Metabolismo

;

Nutrición

;

Concentración

;

Plasma sanguíneo

;

Suplementación

;

Quercetina

;

Dosis diaria

;

Localisation / Location

INIST-CNRS, Cote INIST : 2042, 35400019652743.0050

Nº notice refdoc (ud4) : 20612245



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