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Titre du document / Document title

Serum and salivary oxidative analysis in Complex Regional Pain Syndrome

Auteur(s) / Author(s)

EISENBERG Elon (1 2) ; SHTAHL Shalom (2 3) ; GELLER Rimma (1) ; REZNICK Abraham Z. (2 4) ; SHARF Ordi (1 2 3) ; RAVBINOVICH Meirav (1 3) ; ERENREICH Adam (1 3) ; NAGLER Rafael M. (2 5) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Pain Relief Unit, Rambam Medical Center, Haifa, ISRAEL
(2) Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, ISRAEL
(3) Department of Hand Surgery, Rambam Medical Center, Haifa, ISRAEL
(4) Department of Anatomy and Cell Biology, Rambam Medical Center, Haifa, ISRAEL
(5) Oral and Maxillofacial Surgery Department and Oral Biochemistry Laboratory, Rambam Medical Center, Bat Galim, 31096 Haifa, ISRAEL

Résumé / Abstract

Although both inflammatory and neural mechanisms have been suggested as potential contributors to Complex Regional Pain Syndrome type I (CRPS-I), the pathogenesis of the syndrome is still unclear. Clinical trials have shown that free radical scavengers can reduce signs and symptoms of CRPS-I, indirectly suggesting that free radicals and increased oxidative stress are involved in the pathogenesis of CRPS-I. This study investigated this premise by determining the levels of antioxidants in the serum and saliva of 31 patients with CRPS-I and in a control group of 21 healthy volunteers. Serum lipid peroxidation products (MDA) and all antioxidative parameters analyzed were significantly elevated in CRPS-I patients: median salivary peroxidase and superoxide dismutase (SOD) activity values, uric acid (UA) concentration and total antioxidant status (TAS) values were higher in CRPS-I patients by 150% (p = 0.01), 280% (p = 0.04), 60% (P = 0.0001), and 200% (p = 0.0003), respectively, as compared with controls. Similar although not as extensive pattern of oxidative changes were found in the serum: mean serum UA and MDA concentrations and TAS value in the CRPS-I patients were higher by 16% (p - 0.04), 25% (p = 0.02), and 22% (p = 0.05), respectively, than in the controls. Additionally, median salivary albumin concentration and median salivary LDH activities in the patients were 2.5 times (p = 0.001) and 3.1 (p = 0.004) times higher than in the controls. The accumulated data show that free radicals are involved in the pathophysiology of CRPS-I, which is reflected both in serum and salivary analyses. These data could be used for both diagnostic and therapeutic purposes in CRPS-I patients.

Revue / Journal Title

Pain    ISSN  0304-3959   CODEN PAINDB 

Source / Source

2008, vol. 138, no1, pp. 226-232 [7 page(s) (article)] (44 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Philadelphia, PA, ETATS-UNIS  (1975) (Revue)

Mots-clés anglais / English Keywords

Cardiovascular disease

;

Nervous system diseases

;

Diseases of the autonomic nervous system

;

Enzyme

;

Oxidoreductases

;

Peroxidases

;

Human

;

Ischemia

;

Pain

;

Reflex sympathetic dystrophy

;

Pathophysiology

;

Superoxide dismutase

;

Complex regional pain syndrome

;

Peroxidase

;

Lipids

;

Saliva

;

Oxidative stress

;

Sign

;

Free radical

;

Clinical trial

;

Pathogenesis

;

Mots-clés français / French Keywords

Pathologie de l'appareil circulatoire

;

Pathologie du système nerveux

;

Pathologie du système nerveux autonome

;

Enzyme

;

Oxidoreductases

;

Peroxidases

;

Homme

;

Ischémie

;

Douleur

;

Dystrophie sympathique réflexe

;

Physiopathologie

;

Superoxide dismutase

;

Syndrome douloureux régional complexe

;

Peroxidase

;

Lipide

;

Salive

;

Stress oxydatif

;

Signe

;

Radical libre

;

Essai clinique

;

Pathogénie

;

Mots-clés espagnols / Spanish Keywords

Aparato circulatorio patología

;

Sistema nervioso patología

;

Sistema nervioso autónomo patología

;

Enzima

;

Oxidoreductases

;

Peroxidases

;

Hombre

;

Isquemia

;

Dolor

;

Distrofia simpática refleja

;

Fisiopatología

;

Superoxide dismutase

;

Dolor regional complejo síndrome

;

Peroxidase

;

Lípido

;

Saliva

;

Estrés oxidativo

;

Signo

;

Radical libre

;

Ensayo clínico

;

Patogenia

;

Mots-clés d'auteur / Author Keywords

Complex Regional Pain Syndrome type I (CRPS-I)

;

Neuropathic pain

;

Inflammation

;

Ischemia

;

Oxidative stress

;

Antioxidants

;

Free radicals

;

Localisation / Location

INIST-CNRS, Cote INIST : 17241, 35400019744219.0260

Nº notice refdoc (ud4) : 20578230



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