Titre du document / Document title

Low dose amitriptyline in ankylosing spondylitis : A short term, double blind, placebo controlled study

Auteur(s) / Author(s)

KOH W.-H. ; PANDE I. ; SAMUELS A. ; JONES S. D. ; CALIN A. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Moulmein Road, SINGAPOUR
Royal National Hospital for Rheumatic Diseases, Bath, ROYAUME-UNI

Résumé / Abstract

Objective. To define the effect of low dose amitriptyline on fatigue, pain, and stiffness in patients with ankylosing spondylitis (AS). Methods. One hundred consecutive patients with AS were randomized to receive low dose amitriptyline up to 30 mg nightly or placebo for 2 weeks. Patients were assessed by the Bath Ankylosing Spondylitis Disease Activity (BASDAI) and Functional (BASFI) Indices pre and post-treatment. Results. Eighty-eight patients (44 amitriptyline, 44 placebo) completed the study. Eight (5 amitriptyline, 3 placebo) stopped treatment because of side effects (e.g., drowsiness, dryness of mouth) and 4 provided insufficient data. Compared to placebo, the patients taking amitriptyline showed significantly greater improvement in restful sleep (66 vs 20%; p < 0.001) and their disease activity scores [BASDAI amitriptyline 1.18 (23%) vs placeho ().52 (10%); p = 0.0241. All other variables showed a trend to greater improvement by amitriptyline. although the differences were not statistically significant. Conclusion. (1) In a 2 week study, low dose amitriptyline significantly improved sleep in AS and was well tolerated; (2) as defined by BASDAI, there was a significant reduction in disease activity with amitriptyline; (3) compared to placebo, there was a nonsignificant trend toward improvement in function; and (4) in spite of improvement in pain, fatigue, and sleep with amitriptyline, stiffness was not increased.

Revue / Journal Title

Journal of rheumatology   ISSN 0315-162X   CODEN JRHUA9 

Source / Source

1997, vol. 24, n^o11, pp. 2158-2161 (25 ref.)

Langue / Language

Anglais

Editeur / Publisher

Journal of Rheumatology Publishing, Toronto, ON, CANADA  (1974) (Revue)

Mots-clés anglais / English Keywords

Ankylosing spondylitis ; Short term ; Clinical trial ; Amitriptyline ; Low dose ; Treatment ; Asthenia ; Pain ; Biological activity ; Human ; Chemotherapy ; Treatment efficiency ; Chronic ; Tricyclic compound ; Diseases of the osteoarticular system ; Inflammatory joint disease ; Spondylarthropathy ;

Mots-clés français / French Keywords

Spondylarthrite ankylosante ; Court terme ; Essai clinique ; Amitriptyline ; Dose faible ; Traitement ; Asthénie ; Douleur ; Activité biologique ; Homme ; Chimiothérapie ; Efficacité traitement ; Chronique ; Composé tricyclique ; Système ostéoarticulaire pathologie ; Rhumatisme inflammatoire ; Spondylarthropathie ;

Mots-clés espagnols / Spanish Keywords

Espondiloartritis anquilosante ; Corto plazo ; Ensayo clínico ; Amitriptilina ; Dosis débil ; Tratamiento ; Astenia ; Dolor ; Actividad biológica ; Hombre ; Quimioterapia ; Eficacia tratamiento ; Crónico ; Compuesto tricíclico ; Sistema osteoarticular patología ; Reumatismo inflamatorio ; Espondilartropatia ;

Localisation / Location

INIST-CNRS, Cote INIST : 16024, 35400006952882.0190