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Titre du document / Document title

Royal Jelly Peptides Inhibit Lipid Peroxidation In Vitro and In Vivo

Auteur(s) / Author(s)

GUO Hang (1) ; EKUSA Ai (1) ; IWAI Koji (1) ; YONEKURA Masami (2) ; TAKAHATA Yoshihisa (1) ; MORIMATSU Fumiki (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) R & D Center, Nippon Meat Packers, Inc, Tsukuba, Ibaraki 300-2646, JAPON
(2) Laboratory of Food Functionality, School of Agriculture, Ibaraki University, Ami, Ibaraki 300-0393, JAPON

Résumé / Abstract

Royal jelly peptides (RJPx) isolated from hydrolysates of water-soluble royal jelly proteins prepared with protease P exhibited significantly stronger hydroxyl radical-scavenging activity (p<0.001), and antioxidant activity against lipid peroxidation (LPO, p<0.001), than did water-soluble royal jelly protein (WSRJP) in vitro. We also investigated the in vivo antioxidant activity of RJPx against ferric nitrilotriacetate (Fe-NTA)-induced LPO. Male Wistar rats were divided into a control group (Group C), an Fe-NTA group (Group Fe), and an Fe-NTA with RJPx group (Group Fe+R). Rats in Group Fe+R were fed RJPx (2 g/ kg body weight) daily for 5 wk. Fe-NTA (8 mg Fe/kg body weight) was then intraperitoneally injected, and serum lipid levels were examined 2 h later. Serum total cholesterol (TC) levels were lower (p<0.05) while low-density lipoprotein (LDL) and LPO were significantly higher (p<0.01) in Group Fe than in Group C. TC (p<0.05) and LPO levels (p<0.01) were lower in Group Fe+R than in Group Fe. Our data suggest that RJPx may inhibit LPO both in vitro and in vivo.

Revue / Journal Title

Journal of nutritional science and vitaminology    ISSN  0301-4800 

Source / Source

2008, vol. 54, no3, pp. 191-195 [5 page(s) (article)] (41 ref.)

Langue / Language

Anglais

Editeur / Publisher

Center for Academic Publications Japan, Tokyo, JAPON  (1973) (Revue)

Mots-clés anglais / English Keywords

Antioxidant

;

Biological activity

;

Inhibition

;

Royal jelly

;

In vivo

;

In vitro

;

Peroxidation

;

Lipids

;

Peptides

;

Mots-clés français / French Keywords

Antioxydant

;

Activité biologique

;

Inhibition

;

Gelée royale

;

In vivo

;

In vitro

;

Peroxydation

;

Lipide

;

Peptide

;

Mots-clés espagnols / Spanish Keywords

Antioxidante

;

Actividad biológica

;

Inhibición

;

Jalea real

;

In vivo

;

In vitro

;

Peroxidación

;

Lípido

;

Péptido

;

Mots-clés d'auteur / Author Keywords

royal jelly peptides

;

lipid peroxidation

;

antioxidative activity

;

Localisation / Location

INIST-CNRS, Cote INIST : 8167, 35400019644062.0020

Nº notice refdoc (ud4) : 20551289



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