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Titre du document / Document title

GabaB receptors activation in the NTS blocks the glycemic responses induced by carotid body receptor stimulation

Auteur(s) / Author(s)

LEMUS Monica (1) ; MONTERO Sergio (1 2) ; CADENAS José Luis (1) ; LARA José Jesus (1) ; TEJEDA-CHAVEZ Héctor Rafael (1) ; ALVAREZ-BUYLLA Ramon (1) ; ROCES DE ALVAREZ-BUYLLA Elena (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) CUIB, Universidad de Colima, Colima, Col. 28045, MEXIQUE
(2) Facultad de Medicina, Universidad de Colima, Colima, Col. 28045, MEXIQUE

Résumé / Abstract

The carotid body receptors participate in glucose regulation sensing glucose levels in blood entering the cephalic circulation. The carotid body receptors information, is initially processed within the nucleus tractus solitarius (NTS) and elicits changes in circulating glucose and brain glucose uptake. Previous work has shown that γ-aminobutyric acid (GABA) in NTS modulates respiratory reflexes, but the role of GABA within NTS in glucose regulation remains unknown. Here we show that GABAB receptor agonist (baclofen) or antagonists (phaclofen and CGP55845A) locally injected into NTS modified arterial glucose levels and brain glucose retention. Control injections outside NTS did not elicit these responses. In contrast, GABAA agonist and antagonist (muscimol or bicuculline) produced no significant changes in blood glucose levels. When these GABAergic drugs were applied before carotid body receptors stimulation, again, only GABAB agonist or antagonist significantly affected glycemic responses; baclofen microinjection significantly reduced the hyperglycemic response and brain glucose retention observed after carotid body receptors stimulation, while phaclofen produced the opposite effect, increasing significantly hyperglycemia and brain glucose retention. These results indicate that activation of GABAB, but not GABAA, receptors in the NTS modulates the glycemic responses after anoxic stimulation of the carotid body receptors, and suggest the presence of a tonic inhibitory mechanism in the NTS to avoid hyperglycemia.

Revue / Journal Title

Autonomic neuroscience : basic & clinical    ISSN  1566-0702 

Source / Source

2008, vol. 141, no1-2, pp. 73-82 [10 page(s) (article)] (1 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (2000) (Revue)

Mots-clés anglais / English Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Central nervous system

;

Encephalon

;

Animal

;

Autonomic nervous system

;

Rat

;

Sodium

;

Glucose

;

Gabaergic receptor

;

Solitary nucleus

;

Reflex

;

Chemoreceptor

;

Stimulation

;

Biological receptor

;

Carotid body

;

Gabaergic receptor B

;

Mots-clés français / French Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Système nerveux central

;

Encéphale

;

Animal

;

Système nerveux autonome

;

Rat

;

Sodium

;

Glucose

;

Récepteur gabaergique

;

Noyau du faisceau solitaire

;

Réflexe

;

Chimiorécepteur

;

Stimulation

;

Récepteur biologique

;

Corpuscule carotidien

;

Récepteur gabaergique B

;

Mots-clés espagnols / Spanish Keywords

Vertebrata

;

Mammalia

;

Rodentia

;

Sistema nervioso central

;

Encéfalo

;

Animal

;

Sistema nervioso autónomo

;

Rata

;

Sodio

;

Glucosa

;

Receptor gabaminérgico

;

Núcleo fascículo solitario

;

Reflejo

;

Quimioreceptor

;

Estimulación

;

Receptor biológico

;

Cuerpo carotídeo

;

Receptor gabaminérgico B

;

Mots-clés d'auteur / Author Keywords

Carotid chemoreceptor reflex

;

Nucleus tractus solitarius

;

GABA receptors

;

Glucose

;

Sodium cyanide

;

Rats

;

Localisation / Location

INIST-CNRS, Cote INIST : 18294, 35400019641639.0090

Nº notice refdoc (ud4) : 20538933



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