Titre du document / Document title

Successful induction of ovulation in normogonadotrophic clomiphene resistant anovulatory women by combined naltrexone and clomiphene citrate treatment

Auteur(s) / Author(s)

ROOZENBURG B. J. ⁽¹⁾ ; VAN DESSEL H. J. H. M. ⁽¹⁾ ; EVERS J. L. H. ⁽²⁾ ; BOTS R. S. G. M. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Division of Fertility, Department of Obstetrics and Gynaecology, St Elisabeth Hospital, Hilvarenbeekseweg 60, 5022 GC Tilburg, PAYS-BAS
⁽²⁾ Department of Obstetrics and Gynaecology, Academic Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, PAYS-BAS

Résumé / Abstract

Patients suffering from normogonadotrophic anovulation and infertility are initially treated with clomiphene citrate. Those who do not respond to clomiphene citrate usually receive gonadotrophin treatment which is labour-intensive, expensive, and associated with an increased risk of multiple pregnancies and ovarian hyperstimulation syndrome. We treated 22 patients with clomiphene resistant normogonadotrophic anovulation with naltrexone (an opioid receptor blocker) alone or naltrexone in combination with an anti-oestrogen. In 19 patients ovulation and resumption of a regular menstrual cycle was achieved and in 12 out of 19 a singleton pregnancy was observed. In conclusion, ovulation can be induced successfully using naltrexone alone or naltrexone in combination with an anti-oestrogen in clomiphene citrate resistant anovulatory patients. Compared to gonadotrophin induction of ovulation, this method is safe, simple and inexpensive.

Revue / Journal Title

Human reproduction   ISSN 0268-1161   CODEN HUREEE 

Source / Source

1997, vol. 12, n^o8, pp. 1720-1722 (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Oxford University Press, Oxford, ROYAUME-UNI  (1986) (Revue)

Mots-clés anglais / English Keywords

Menstruation disorders ; Female genital diseases ; Treatment ; Ovulation inducer ; Drug combination ; Drug interaction ; Antiestrogen ; Clomifene ; Naltrexone ; Non steroidal estrogen ; Morphinan derivatives ; Antihormone ; Female ; Anovulation ;

Mots-clés français / French Keywords

Cycle menstruel pathologie ; Appareil génital femelle pathologie ; Traitement ; Inducteur ovulation ; Association médicamenteuse ; Interaction médicamenteuse ; Antioestrogène ; Clomifène ; Naltrexone ; Oestrogène non stéroïde ; Morphinane dérivé ; Antihormone ; Femelle ; Anovulation ;

Mots-clés espagnols / Spanish Keywords

Ciclo menstrual patología ; Aparato genital hembra patología ; Tratamiento ; Inductor ovulación ; Asociación medicamentosa ; Interacción medicamentosa ; Antiestrógeno ; Clomifeno ; Naltrexona ; Estrógeno no esteroideo ; Morphinano derivado ; Antihormona ; Hembra ; Anovulación ;

Localisation / Location

INIST-CNRS, Cote INIST : 21337, 35400006948732.0260