Titre du document / Document title

Androgen disruption and toxicity tests of Butea superba Roxb., a traditional herb used for treatment of erectile dysfunction, in male rats

Auteur(s) / Author(s)

CHERDSHEWASART Wichai ⁽¹⁾ ; BHUNTAKU Papong ^{(1 2)} ; PANRIANSAEN Rattana ^{(3 4)} ; DAHLAN Winai ⁽⁵⁾ ; MALAIVIJITNOND Suchinda ^{(1 2)} ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Biology, Faculty of Science, Chulalongkom University, Phyathai Road, Patumwan, Bangkok 10330, THAILANDE
⁽²⁾ Primate Research Unit, Faculty of Science, Chulalongkorn University, Phyathai Road, Patumwan, Bangkok 10330, THAILANDE
⁽³⁾ Program of Biotechnology, Faculty of Science, Chulalongkom University, Phyathai Road, Patumwan, Bangkok 10330, THAILANDE
⁽⁴⁾ Program of Applied Thai Traditional Medicine, Faculty of Science and Technology, Suan Sunandha Rajabhat University, Dusit, Bangkok 10300, THAILANDE
⁽⁵⁾ Lipid and Fat Sciences Research Center, Faculty of Allied Health Science, Chulalongkorn University, Phyathai Road, Patumwan, Bangkok 10330, THAILANDE

Résumé / Abstract

Objective: To evaluate the effects of the tuberous powder of Butea superba Roxb. (Leguminosae) on blood testosterone and luteinizing hormone (LH), and toxicity in male rats. Methods: Adult male Wistar rats were orally treated with 0, 10, 100, 150 or 200 mg/kg BW/day of B. superba powder suspension in 0.7 ml distilled water for 90 consecutive days. Blood samples were collected every 30 days and submitted to testosterone and LH analysis. On the 90th day of treatment, blood and the main organs were collected for haematological and histopathological analysis, respectively. Results: The adverse effects found included an increase in spleen relative weight, and increased serum level of alkaline phosphatase (ALP) and aspartate aminotransferase (AST) in rats treated with 150 mg/kg BW/day B. superba powder. At 200 mg/kg BW/day treatment, rats showed significant decreased and increased blood levels of neutrophil and eosinophil, respectively, and a decrease in serum creatinine levels. Serum hormonal analysis revealed a dose-dependent decrease in testosterone, but not LH, in rats treated with 150 and 200 mg/kg BW/day B. superba powder. Conclusion: Subchronic treatment of B. superba tuberous powder suspension at high doses in male rats exhibited adverse effects to blood chemistry, haematology, and blood testosterone level. The results of the study should initiate awareness of the possible adverse risk of over-dose consumption of B. superba products for treatment of erectile dysfunction (ED) in mature males.

Revue / Journal Title

Maturitas   ISSN 0378-5122   CODEN MATUDK 

Source / Source

2008, vol. 60, n^o2, pp. 131-137 [7 page(s) (article)] (36 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier Science, Shannon, IRLANDE  (1978) (Revue)

Mots-clés anglais / English Keywords

Pharmacognosy ; Adenohypophyseal hormone ; Gonadotropin ; Phenols ; Polyphenol ; Male genital diseases ; Asia ; Vertebrata ; Mammalia ; Rodentia ; Spermatophyta ; Angiospermae ; Dicotyledones ; Endocrine disruptor ; Thailand ; Plant origin ; Medicinal plant ; Luteinizing hormone ; Testosterone ; Phytoestrogen ; Flavonoid ; Rat ; Animal ; Male ; Erection disorders ; Treatment ; Folk medicine ; Butea superba ; Leguminosae ; Toxicity ; Androgen ;

Mots-clés français / French Keywords

Pharmacognosie ; Hormone adénohypophysaire ; Gonadotrophine ; Phénols ; Polyphénol ; Pathologie de l'appareil génital mâle ; Asie ; Vertebrata ; Mammalia ; Rodentia ; Spermatophyta ; Angiospermae ; Dicotyledones ; Perturbateur endocrinien ; Thaïlande ; Origine végétale ; Plante médicinale ; LH ; Testostérone ; Phytoestrogène ; Flavonoïde ; Rat ; Animal ; Mâle ; Pathologie de l'érection ; Traitement ; Médecine traditionnelle ; Butea superba ; Leguminosae ; Toxicité ; Androgène ;

Mots-clés espagnols / Spanish Keywords

Farmacognosia ; Hormona adenohipofisaria ; Gonadotropina ; Fenoles ; Polifenol ; Aparato genital macho patología ; Asia ; Vertebrata ; Mammalia ; Rodentia ; Spermatophyta ; Angiospermae ; Dicotyledones ; Disruptor endocrino ; Tailandia ; Origen vegetal ; Planta medicinal ; LH ; Testosterona ; Fitoestrógeno ; Flavonoide ; Rata ; Animal ; Macho ; Erección patología ; Tratamiento ; Medicina tradicional ; Butea superba ; Leguminosae ; Toxicidad ; Andrógeno ;

Mots-clés d'auteur / Author Keywords

Androgen disruption ; Butea superba ; Flavonoids ; Phytoestrogen ; Testosterone ;

Localisation / Location

INIST-CNRS, Cote INIST : 18011, 35400019604082.0060