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Titre du document / Document title

The role of iron dysregulation in the pathogenesis of multiple sclerosis : an Egyptian study

Auteur(s) / Author(s)

ABO-KRYSHA N. (1) ; RASHED L. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Neurology, Cairo University, Cairo, EGYPTE
(2) Department of Biochemistry, Cairo University, Cairo, EGYPTE

Résumé / Abstract

Background Iron is essential for virtually all types of cells and organisms. The significance of iron for brain function is reflected by the presence of receptors for transferrin on brain capillary endothelial cells. Iron imbalance is associated with proinflammatory cytokines and oxidative stress, which have been implicated in the pathogenesis of multiple sclerosis (MS). Transferrin receptor (TfR) is the major mediator of iron uptake. Its expression is increased to facilitate iron entrance into the cell. The increased serum level of soluble transferrin receptor (sTfR) may indicate an abnormal intracellular distribution of iron and a decrease in the cytoplasmic compartment. Objective Our objective is to assess the possible role of iron metabolism dysfunction in the pathogenesis of MS. Methods Thirty subjects were selected from the Neurology Department of Kasr El-Aini hospital, Cairo University: 20 MS patients, where nine patients were relapsing and progressive (secondary progressive (SP) of which six were secondary progressive active (SP-A) and three were secondary progressive stable (SP-S)), seven were relapsing-remitting active (RR-A) and four were primary progressive (PP); and 10 control subjects matched in age and sex. Each patient was subjected to a thorough general medical and neurological examination, Kurtzke MS rating scales, laboratory assessment, neuro-imaging, evoked potentials and quantitative determination of the indices of iron metabolism, such as serum iron and sTfR. Results The serum level of sTfR was significantly higher in our MS patients compared with the control group (p = 0.0001). The levels were significantly higher in SP-A (p = 0.001), SP-S (p = 0.01), RR-A (p = 0.0001) and PP (p = 0.003) patients than in controls. Iron values were within normal limits in all patients. The increased serum sTfR level in non-anemic MS patients with active disease reflects the increased iron turnover. The elevation of sTfR levels in stable patients may indicate active inflammation with ongoing oxidative damage that is not detectable by history or examination. Conclusions Iron overload and upregulation of iron-handling proteins, such as TfR, in the MS brain can contribute to pathogenesis of Multiple Sclerosis and iron imbalance is associated with a prooxidative stress and a proinflammatory environment, this suggest that iron could be a target for MS therapy to improve neuronal iron metabolism.

Revue / Journal Title

Multiple sclerosis    ISSN  1352-4585 

Source / Source

2008, vol. 14, no5, pp. 602-608 [7 page(s) (article)] (26 ref.)

Langue / Language

Anglais

Editeur / Publisher

Sage Publications, London, ROYAUME-UNI  (1995) (Revue)

Mots-clés anglais / English Keywords

Central nervous system disease

;

Inflammatory disease

;

Biological receptor

;

Transferrin

;

Pathogenesis

;

Iron

;

Degenerative disease

;

Nervous system diseases

;

Multiple sclerosis

;

Mots-clés français / French Keywords

Pathologie du système nerveux central

;

Maladie inflammatoire

;

Récepteur biologique

;

Transferrine

;

Pathogénie

;

Fer

;

Maladie dégénérative

;

Pathologie du système nerveux

;

Sclérose en plaques

;

Mots-clés espagnols / Spanish Keywords

Sistema nervosio central patología

;

Enfermedad inflamatoria

;

Receptor biológico

;

Transferrina

;

Patogenia

;

Hierro

;

Enfermedad degenerativa

;

Sistema nervioso patología

;

Esclerosis en placa

;

Mots-clés d'auteur / Author Keywords

multiple sclerosis

;

iron

;

transferrin receptor

;

Localisation / Location

INIST-CNRS, Cote INIST : 26577, 35400019758805.0030

Nº notice refdoc (ud4) : 20474422



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