Titre du document / Document title
Cocoa confers life span extension in Drosophila melanogaster
Auteur(s) / Author(s)
BAHADORANI Sepehr (1) ;
HILLIKER Arthur J. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Biology, York University, Toronto, Ontario, M3J 1P3, CANADA
Résumé / Abstract
Cocoa is thought to be an excellent source of antioxidants. Here, we investigated the effects of cocoa supplementation on Drosophila melanogaster life span under different oxidative stress conditions. Our results illustrate that a moderate supplementation of cocoa under normoxia increases the average life span, whereas, at higher concentrations, average life span is normal. Under hyperoxia or in a Cu/Zn-superoxide dismutase-deficient background, cocoa exhibited a strong antioxidant activity, significantly increasing the average life span. Nevertheless, cocoa supplementation in a Mn-superoxide dismutase-deficient background enhanced an earlier mortality accompanied by a loss of climbing ability, indicating that cocoa may act as a pro-oxidant in mitochondria under conditions of extreme oxidative stress. Finally, we illustrate that cocoa also acts as a metal chelator in the presence of excess heavy metals, enhancing larval survival to the adult stage on copper or iron-supplemented medium. Taken together, our results document the antioxidative, pro-oxidative, and metal-chelating effects of cocoa on Drosophila melanogaster life span.
Revue / Journal Title
Nutrition research
ISSN
0271-5317
CODEN NTRSDC
Source / Source
2008, vol. 28, n
o6, pp. 377-382 [6 page(s) (article)] (23 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, New York, NY, ETATS-UNIS
(1981)
(Revue)
Mots-clés anglais / English Keywords
Vertebrata ;
Mammalia ;
Oxidative stress ;
Ageing ;
Senescence ;
Extension ;
Longevity ;
Cocoa ;
Mots-clés français / French Keywords
Vertebrata ;
Mammalia ;
Stress oxydatif ;
Vieillissement ;
Sénescence ;
Extension ;
Longévité ;
Cacao ;
Mots-clés espagnols / Spanish Keywords
Vertebrata ;
Mammalia ;
Estrés oxidativo ;
Envejecimiento ;
Senescencia ;
Extensión ;
Longevidad ;
Cacao ;
Mots-clés d'auteur / Author Keywords
Drosophila melanogaster ;
Cocoa ;
Aging ;
Oxidative stress ;
Heavy metals ;
Localisation / Location
INIST-CNRS, Cote INIST : 18812, 35400019788596.0050
Nº notice refdoc (ud4) : 20443778
