Titre du document / Document title
Glutathione S-transferase variants increase susceptibility for late-onset Alzheimer's disease : association study and relationship with apolipoprotein E ε4 allele
Auteur(s) / Author(s)
PINHEL Marcela A. S. (1) ;
NAKAZONE Marcelo A. (1) ;
CACAO Joao C. (2) ;
PITERI Rafael C. O. (1) ;
DANTAS Raoni T. (1) ;
GODOY Moacir F. (3) ;
GODOY Maria R. P. (2) ;
TOGNOLA Waldir A. (4) ;
CONFORTI-FROES Nivea D. T. (5) ;
SOUZA Dorotéia R. S. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Molecular Biology, Sao José do Rio Preto Medical School, Sao José do Rio Preto, SP, BRESIL
(2) Department of Medicine, Sao José do Rio Preto Medical School, Sao José do Rio Preto, SP, BRESIL
(3) Department of Cardiology and Cardiovascular Surgery, Sao José do Rio Preto Medical School, Sao José do Rio Preto, SP, BRESIL
(4) Department of Neurological Sciences, Sao José do Rio Preto Medical School, Sao José do Rio Preto, SP, BRESIL
(5) Genomic Sector of the Salomao and Zoppi Diagnostic Center, Sao Paulo, SP, BRESIL
Résumé / Abstract
Background: Several factors participate in the pathogenesis of Alzheimer's disease (AD), including free radicals, which when out of balance with their antioxidant capacity contribute to the oxidative stress process and neuronal death. The glutathione S-transferase (GST) polymorphisms are associated with the organism detoxification capacity and can help with the identification of sub-groups that present susceptibility to the development of AD. The aim of this study was to analyze the association of GSTs, including GSTP1, GSTT1 and GSTM1 and apolipoprotein E (apoE) with AD and the distribution of these polymorphisms in the first-degree relatives of patients. Methods: For this, 41 patients with AD, 24 elderly without cognitive deficits (control group), 109 relatives of patients with AD and 41 relatives of controls were studied. A sample of peripheral blood was drawn for leukocyte DNA extraction. The genetic polymorphisms were analyzed by PCR-RFLP. Results: There was a significantly higher frequency of the ε4 allele in the patients (0.21) and in their relatives (0.25) when compared to controls (0.04; p=0.01) and their relatives (0.03; p<0.0001). The V allele of the GSTP1 polymorphism was higher in patients compared to controls (0.35 and 0.19, respectively; p=0.04). In contrast, the presence of the GSTT1 polymorphism prevailed in controls (79%) and their relatives. Conclusions: The V allele may be a risk factor for AD, mainly in the presence of the apoE ε4 allele, while the presence of GSTT1 may indicate protection against the disease.
Revue / Journal Title
Clinical chemistry and laboratory medicine
ISSN
1434-6621
Source / Source
2008, vol. 46, n
o4, pp. 439-445 [7 page(s) (article)] (35 ref.)
Langue / Language
Anglais
Editeur / Publisher
De Gruyter, Berlin, ALLEMAGNE
(1998)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 10319, 35400017279697.0050
Nº notice refdoc (ud4) : 20290591
