Titre du document / Document title
Beneficial effect of shallot (Allium ascalonicum L.) extract on cyclosporine nephrotoxicity in rats
Auteur(s) / Author(s)
WONGMEKIAT O. (1) ;
LEELARUGRAYUB N. (2) ;
THAMPRASERT K. (3) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, THAILANDE
(2) Clinical Biochemistry and Movement Sciences Research Group. Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, THAILANDE
(3) Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, THAILANDE
Résumé / Abstract
The clinical use of an immunosuppressive cyclosporine A (CsA) is limited by its serious nephrotoxic effect. Evidences have suggested the role of oxidative stress in its pathogenesis. Shallot (Allium ascalonicum L.) has recently been shown to possess antioxidative and free radical scavenging abilities. The present study was undertaken to investigate the possible beneficial effect of shallot extract on renal injury caused by CsA. Male Wistar rats were treated orally with vehicle, CsA (25 mg/kg), shallot extract (1 g/kg), and CsA plus shallot extract for 21 days. Renal function, histopathology, tissue malondialdehyde (MDA) and glutathione (GSH) levels were evaluated 24 h after the last treatment. CsA-induced nephrotoxicity was evidenced by increased blood urea nitrogen and serum creatinine, but decreased urea and creatinine clearance. The kidney of CsA treated rats exhibited severe vacuolations and tubular necrosis. CsA also induced oxidative stress, as indicated by increased renal MDA and reduced GSH concentrations. Administration of shallot extract along with CsA counteracted the deleterious effects of CsA on renal dysfunction, oxidative stress markers, and morphological changes. These data indicate the protective potential of shallot extract against CsA nephrotoxicity and suggest a significant contribution of its antioxidant property to this beneficial effect.
Revue / Journal Title
Food and chemical toxicology
ISSN
0278-6915
CODEN FCTOD7
Source / Source
2008, vol. 46, n
o5, pp. 1844-1850 [7 page(s) (article)] (12 p.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Oxford, ROYAUME-UNI
(1982)
(Revue)
Mots-clés anglais / English Keywords
Urinary system ;
Urinary system disease ;
Vertebrata ;
Mammalia ;
Rodentia ;
Spermatophyta ;
Angiospermae ;
Monocotyledones ;
Liliaceae ;
Oxidative stress ;
Rat ;
Animal ;
Nephrotoxicity ;
Kidney ;
Toxicity ;
Kidney disease ;
Immunosuppressive agent ;
Extract ;
Allium ;
Ciclosporin ;
Mots-clés français / French Keywords
Inhibiteur de la calcineurine ;
Appareil urinaire ;
Pathologie de l'appareil urinaire ;
Vertebrata ;
Mammalia ;
Rodentia ;
Spermatophyta ;
Angiospermae ;
Monocotyledones ;
Liliaceae ;
Stress oxydatif ;
Rat ;
Animal ;
Néphrotoxicité ;
Rein ;
Toxicité ;
Pathologie du rein ;
Immunodépresseur ;
Extrait ;
Allium ;
Ciclosporine ;
Mots-clés espagnols / Spanish Keywords
Aparato urinario ;
Aparato urinario patología ;
Vertebrata ;
Mammalia ;
Rodentia ;
Spermatophyta ;
Angiospermae ;
Monocotyledones ;
Liliaceae ;
Estrés oxidativo ;
Rata ;
Animal ;
Nefrotoxicidad ;
Riñón ;
Toxicidad ;
Riñón patología ;
Inmunodepresor ;
Extracto ;
Allium ;
Ciclosporina ;
Mots-clés d'auteur / Author Keywords
Nephrotoxicity ;
Cyclosporine ;
Shallot ;
Oxidative stress ;
Localisation / Location
INIST-CNRS, Cote INIST : 10616, 35400017263808.0500
Nº notice refdoc (ud4) : 20272562
