Titre du document / Document title

Potato (Solanum tuberosum) Juice Exerts an Anticonvulsant Effect in Mice through Binding to GABA Receptors

Auteur(s) / Author(s)

MUCENIECE Ruta ⁽¹⁾ ; SALENIECE Kristine ⁽¹⁾ ; KRIGERE Liga ⁽¹⁾ ; RUMAKS Juris ⁽¹⁾ ; DZIRKALE Zane ⁽¹⁾ ; MEZHAPUKE Rudolfs ⁽²⁾ ; KVIESIS Jorens ⁽³⁾ ; MEKSS Peteris ⁽³⁾ ; KLUSA Vija ⁽¹⁾ ; SCHIÖTH Helgi B. ⁽⁴⁾ ; DAMBROVA Maija ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ University of Latvia, Faculty of Medicine, Riga, LETTONIE
⁽²⁾ Latvian Institute of Organic Synthesis, Riga, LETTONIE
⁽³⁾ University of Latvia, Faculty of Chemistry, Riga, LETTONIE
⁽⁴⁾ Department of Neuroscience, Uppsala University, Biomedical Centre, Uppsala, SUEDE

Résumé / Abstract

Naturally occurring benzodiazepines have been identified in regular food such as wheat and potato, but there is still no evidence that potato extracts can affect CNS responses in vivo. Here we found that undiluted potato juice and potato juice diluted with saline 1:2 administered 10 min intracisternally (i. c.) and 30 min per os before bicuculline exerted significant anticonvulsant activity in the bicuculline-induced seizure threshold test in mice. In vitro, potato juice from different harvests at dilution series from 10% to 0.000001%, diluted 100,000-fold, displaced 50% of γ-aminobutyric acid (GABA) receptor ligand [³H]GABA and diluted 40-fold displaced 50% of [³H]flunitrazepam from binding sites in mice forebrain membranes. The low content of diazepam (0.04 ± 0.01 mg/kg) determined by HPLC and mass spectrometry in the potato extracts could not sustain the anticonvulsant activity of potato juice in vivo; therefore we hypothesized that potato juice might contain GABA_A receptor GABA-site active compounds. The findings of this study suggest that potato juice as well as potato taken as food may have the capacity of influencing brain GABA-ergic activity.

Revue / Journal Title

Planta medica    ISSN  0032-0943   CODEN PLMEAA 

Source / Source

2008, vol. 74, n^o5, pp. 491-496 [6 page(s) (article)] (12 ref.)

Langue / Language

Anglais

Editeur / Publisher

Thieme, Stuttgart, ALLEMAGNE  (1953) (Revue)

Mots-clés anglais / English Keywords

Nervous system diseases

;

Central nervous system disease

;

Cerebral disorder

;

Antagonist

;

Alkaloid

;

Tuber plant

;

Vertebrata

;

Mammalia

;

Rodentia

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Solanaceae

;

Isoquinoline derivatives

;

Plant origin

;

Medicinal plant

;

Pharmacognosy

;

Epilepsy

;

Biological receptor

;

Benzodiazepine derivatives

;

Gabaergic receptor

;

Mouse

;

Animal

;

Anticonvulsant

;

Solanum tuberosum

;

Mots-clés français / French Keywords

Pathologie du système nerveux

;

Pathologie du système nerveux central

;

Pathologie de l'encéphale

;

Antagoniste

;

Alcaloïde

;

Plante à tubercule

;

Vertebrata

;

Mammalia

;

Rodentia

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Solanaceae

;

Dérivé de l'isoquinoléine

;

Origine végétale

;

Plante médicinale

;

Pharmacognosie

;

Epilepsie

;

Bicuculline

;

Récepteur biologique

;

Dérivé de la benzodiazépine

;

Récepteur gabaergique

;

Souris

;

Animal

;

Anticonvulsivant

;

Solanum tuberosum

;

Mots-clés espagnols / Spanish Keywords

Sistema nervioso patología

;

Sistema nervosio central patología

;

Encéfalo patología

;

Antagonista

;

Alcaloide

;

Planta con tubérculo

;

Vertebrata

;

Mammalia

;

Rodentia

;

Spermatophyta

;

Angiospermae

;

Dicotyledones

;

Solanaceae

;

Isoquinoleína

;

Origen vegetal

;

Planta medicinal

;

Farmacognosia

;

Epilepsia

;

Receptor biológico

;

Benzodiazepina derivado

;

Receptor gabaminérgico

;

Ratón

;

Animal

;

Anticonvulsivante

;

Solanum tuberosum

;

Mots-clés d'auteur / Author Keywords

Solanum tuberosum L

;

Solanaceae

;

potato

;

benzodiazepine

;

GABA receptors

;

radioligand receptor binding

;

bicuculline seizures

;

Localisation / Location

INIST-CNRS, Cote INIST : 9624, 35400017269797.0020