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Titre du document / Document title

Identification of Lysophosphatidylcholine-Chlorohydrin in Human Atherosclerotic Lesions

Auteur(s) / Author(s)

MESSNER M. C. ; ALBERT C. J. ; MCHOWAT J. ; FORD D. A. ;

Résumé / Abstract

Lysophosphatidylcholine (LysoPtdCho) levels are elevated in sera in patients with atherosclerosis and in atherosclerotic tissue. Previous studies have shown that reactive chlorinating species attack plasmalogens in human coronary artery endothelial cells (HCAEC), forming lysoPtdCho and lysoPtdCho-chlorohydrin (lysoPtdCho-ClOH). The results herein demonstrate for the first time that lysoPtdCho-ClOH is elevated over 60-fold in human atherosclerotic lesions. In cultured HCAEC, 18:0 lysoPtdCho-ClOH led to a statistically significant increase in P-selectin cell-surface expression, but unlike 18:1 lysoPtdCho did not lead to cyclooxygenase-2 protein expression. These data show that 18:0 lysoPtdCho-ClOH is elevated in atherosclerotic tissue and may have unique pro-atherogenic properties compared to lysoPtdCho.

Revue / Journal Title

Lipids    ISSN  0024-4201   CODEN LPDSAP 

Source / Source

2008, vol. 43, no3, pp. 243-249 [7 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Springer, Heidelberg, ALLEMAGNE  (1966) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 12988, 35400018320821.0060

Nº notice refdoc (ud4) : 20164978



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