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Titre du document / Document title

Short and long duration transcranial direct current stimulation (tDCS) over the human hand motor area

Auteur(s) / Author(s)

FURUBAYASHI Toshiaki (1) ; TERAO Yasuo (1) ; ARAI Noritoshi (1) ; OKABE Shingo (1) ; MOCHIZUKI Hitoshi (2) ; HANAJIMA Ritsuko (1) ; HAMADA Masashi (1) ; YUGETA Akihiro (1) ; INOMATA-TERADA Satomi (1) ; UGAWA Yoshikazu (3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Neurology, Division of Neuroscience, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JAPON
(2) Department of Neurology, Higashi-Saitama National Hospital, Saitama, JAPON
(3) Department of Neurology, School of Medicine, Fukushima Medical University, Fukushima, JAPON

Résumé / Abstract

The aim of the present paper is to study effects of short and long duration transcranial direct current stimulation (tDCS) on the human motor cortex. In eight normal volunteers, motor evoked potentials (MEPs) induced by transcranial magnetic stimulation (TMS) were recorded from the right first dorsal interosseous muscle, and tDCS was given with electrodes over the left primary motor cortex (Ml) and the contralateral orbit. We performed two experiments: one for short duration tDCS (100 ms, 1, 3 or 5 mA) and the other for long duration tDCS (10 min, 1 mA). The stimulus onset asynchrony (SOA) between the onset of tDCS and TMS were 1-7 and 10-120 ms for the former experiment. In the latter experiment, TMS was given 0-20 min after the end of 10 min tDCS. We evaluated the effect of tDCS on the motor cortex by comparing MEPs conditioned by tDCS with control MEPs. Cathodal short duration tDCS significantly reduced the size of responses to motor cortical stimulation at SOAs of 1-7 ms when the intensity was equal to or greater than 3 mA. Anodal short duration tDCS significantly increased MEPs when the intensity was 3 mA, but the enhancement did not occur when using 5 mA conditioning stimulus. Moreover, both anodal and cathodal short duration tDCS decreased responses to TMS significantly at SOAs of 20-50 ms and enhanced them at an SOA of 90 ms. Long duration cathodal tDCS decreased MEPs at 0 and 5 min after the offset of tDCS and anodal long duration tDCS increased them at 1 and 15 min. We conclude that the effect at SOAs less than 10 ms is mainly caused by acute changes in resting membrane potential induced by tDCS. The effect at SOAs of 20-100 ms is considered to be a nonspecific effect of a startle-like response produced by activation of skin sensation at the scalp. The effect provoked by long duration tDCS may be short-term potentiation or depression like effects.

Revue / Journal Title

Experimental brain research    ISSN  0014-4819   CODEN EXBRAP 

Source / Source

2008, vol. 185, no2, pp. 279-286 [8 page(s) (article)] (3/4 p.)

Langue / Language

Anglais

Editeur / Publisher

Springer, Heidelberg, ALLEMAGNE  (1966) (Revue)

Mots-clés anglais / English Keywords

Electrophysiology

;

Motor pathway

;

Central nervous system

;

Encephalon

;

Human

;

Synaptic plasticity

;

Potentiation

;

Sensation

;

Dorsal interosseous muscle

;

Magnetic stimulus

;

Transcranial magnetic stimulation

;

Evoked potential

;

Motor evoked potential

;

Motor cortex

;

Hand

;

Mots-clés français / French Keywords

Electrophysiologie

;

Voie motrice

;

Système nerveux central

;

Encéphale

;

Homme

;

Plasticité synaptique

;

Potentialisation

;

Sensation

;

Muscle interosseux dorsal

;

Stimulus magnétique

;

Stimulation magnétique transcrânienne

;

Potentiel évoqué

;

Potentiel évoqué moteur

;

Cortex moteur

;

Main

;

Mots-clés espagnols / Spanish Keywords

Electrofisiología

;

Vía motora

;

Sistema nervioso central

;

Encéfalo

;

Hombre

;

Plasticidad sináptica

;

Potencialización

;

Sensación

;

Músculo dorsal interóseo

;

Estímulo magnético

;

Estimulación magnética transcraneal

;

Potencial evocado

;

Potencial evocado motor

;

Corteza motora

;

Mano

;

Mots-clés d'auteur / Author Keywords

Transcranial direct current stimulation (tDCS)

;

Transcranial magnetic stimulation (TMS)

;

Motor cortex

;

Localisation / Location

INIST-CNRS, Cote INIST : 12535, 35400017508038.0110

Nº notice refdoc (ud4) : 20106822



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