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Titre du document / Document title

First Administration of Cytidine Diphosphocholine and Galantamine in Schizophrenia : A Sustained α7 Nicotinic Agonist Strategy

Auteur(s) / Author(s)

DEUTSCH Stephen I. ; SCHWARTZ Barbara L. ; SCHOOLER Nina R. ; ROSSE Richard B. ; MASTROPAOLO John ; GASKINS Brooke ;

Résumé / Abstract

Converging lines of evidence suggest pathophysiology of α7 nicotinic acetylcholine receptors (α7 nAChRs) in schizophrenia. This pilot study was designed to test the tolerability, safety, and preliminary efficacy of chronic administration of an α7 nAChR agonist strategy involving combination treatment of cytidine diphosphocholine (CDP-choline; 2 g/d), a dietary source of the a7 nAChR agonist choline, and galantamine (24 mg/d), a positive allosteric modulator of nAChRs that was prescribed to prevent choline from becoming a functional antagonist and improve the efficiency of coupling the binding of choline to channel opening. The combination of CDP-choline and galantamine was administered to 6 schizophrenic patients with residual symptoms in a 12-week, open-label trial. Patients were maintained on stable dose regimens of antipsychotic medications for 4 weeks before study entry and for the trial duration. All reached target doses of both agents and completed the trial. Transient side effects resolved without slowing of dose titration. Gastrointestinal adverse effects were most common. Of the 6 patients, 5 showed reduction in Clinical Global Impressions severity scores and Positive and Negative Syndrome Scale total scores. Three patients requested continuation of the adjunctive combination at the end of the trial. These results suggest further investigation of the combination of CDP-choline and galantamine as an α7 nAChR agonist intervention.

Revue / Journal Title

Clinical neuropharmacology    ISSN  0362-5664   CODEN CLNEDB 

Source / Source

2008, vol. 31, no1, pp. 34-39 [6 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams & Wilkins, Hagerstown, MD, ETATS-UNIS  (1976) (Revue)

Mots-clés d'auteur / Author Keywords

α7 nicotinic receptors

;

CDP-choline

;

galantamine

;

schizophrenia

;

acetylcholine

;

Localisation / Location

INIST-CNRS, Cote INIST : 16720, 35400016188899.0040

Nº notice refdoc (ud4) : 20041669



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