Titre du document / Document title

Modulation of food intake following deep brain stimulation of the ventromedial hypothalamus in the vervet monkey : Laboratory investigation

Auteur(s) / Author(s)

LACAN Goran ⁽¹⁾ ; DE SALLES Antonio A. F. ^{(2 3)} ; GORGULHO Alessandra A. ⁽²⁾ ; KRAHL Scott E. ^{(2 3)} ; FRIGHETTO Leonardo ⁽²⁾ ; BEHNKE Eric J. ⁽²⁾ ; MELEGA William P. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, ETATS-UNIS
⁽²⁾ Division of Neurosurgery, Department of Surgery, David Geffen School of Medicine at UCLA, ETATS-UNIS
⁽³⁾ VA Greater Los Angeles Healthcare System, Los Angeles, California, ETATS-UNIS

Résumé / Abstract

Object. Deep brain stimulation (DBS) has become an effective therapy for an increasing number of brain disorders. Recently demonstrated DBS of the posterior hypothalamus as a safe treatment for chronic intractable cluster headaches has drawn attention to this target, which is involved in the regulation of diverse autonomic functions and feeding behavior through complex integrative mechanisms. In this study, the authors assessed the feasibility of ventromedial hypothalamus (VMH) DBS in freely moving vervet monkeys to modulate food intake as a model for the potential treatment of eating disorders. Methods. Deep brain stimulation electrodes were bilaterally implanted into the VMH of 2 adult male vervet monkeys by using the stereotactic techniques utilized in DBS in humans. Stimulators were implanted subcutaneously on the upper back, allowing ready access to program stimulation parameters while the animal remained conscious and freely moving. In anesthetized animals, intraoperatively and 6-10 weeks postsurgery, VMH DBS parameters were selected according to minimal cardiovascular and autonomic nervous system responses. Thereafter, conscious animals were subjected to 2 cycles of VMH DBS for periods of 8 and 3 days, and food intake and behavior were monitored. Animals were then killed for histological verification of probe placement. Results. During VMH DBS, total food consumption increased. The 3-month bilateral implant of electrodes and subsequent periods of high-frequency VMH stimulation did not result in significant adverse behavioral effects. Conclusions. This is the first study in which techniques of hypothalamic DBS in humans have been applied in freely moving nonhuman primates. Future studies can now be conducted to determine whether VMH DBS can change hypothalamic responsivity to endocrine signals associated with adiposity for long-term modulation of food intake.

Revue / Journal Title

Journal of neurosurgery   ISSN 0022-3085   CODEN JONSAC 

Source / Source

2008, vol. 108, n^o2, pp. 336-342 [7 page(s) (article)] (56 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Association of Neurological Surgeons, Park Ridge, IL, ETATS-UNIS  (1944) (Revue)

Mots-clés anglais / English Keywords

Nutrition disorder ; Eating disorder ; Vertebrata ; Mammalia ; Primates ; Nutritional status ; Laboratory investigations ; Monkey ; Animal ; Hypothalamus ; Encephalon ; Food intake ; Obesity ; Anorexia nervosa ;

Mots-clés français / French Keywords

Trouble de la nutrition ; Trouble du comportement alimentaire ; Vertebrata ; Mammalia ; Primates ; Etat nutritionnel ; Examen laboratoire ; Singe ; Animal ; Hypothalamus ; Encéphale ; Consommation alimentaire ; Obésité ; Anorexie mentale ;

Mots-clés espagnols / Spanish Keywords

Trastorno nutricíon ; Trastorno conducta alimentaria ; Vertebrata ; Mammalia ; Primates ; Estado nutricional ; Examen laboratorio ; Mono ; Animal ; Hipotálamo ; Encéfalo ; Consumo alimenticio ; Obesidad ; Anorexia mental ;

Mots-clés d'auteur / Author Keywords

anorexia nervosa ; feeding behavior ; nonhuman primate ; obesity ;

Localisation / Location

INIST-CNRS, Cote INIST : 6023, 35400016188485.0190