Titre du document / Document title

Significado pronóstico del aclaramiento de creatinina en pacientes con insuficiencia cardiaca y creatinina sérica normal = Prognostic Significance of Creatinine Clearance Rate in Patients With Heart Failure and Normal Serum Creatinine

Auteur(s) / Author(s)

ZAMORA Elisabet ; LUPON Josep ; URRUTIA Agustin ; GONZALEZ Beatriz ; MAS Dolores ; DIEZ Crisanto ; ALTIMIR Salvador ; VALLE Vicente ;

Résumé / Abstract

Kidney failure is an important prognostic factor in patients with heart failure. Renal function is usually evaluated by measuring the serum creatinine level. However, a normal creatinine level can mask established kidney failure. We investigated the prognostic significance of the estimated creatinine clearance rate (Cockcroft formula) in 235 patients with heart failure and a normal serum creatinine level. The two-year mortality rate was significantly higher in patients who had established kidney disease (i.e., a creatinine clearance rate <60 mL/min) than in those who did not (35.1% vs. 10.1%, P<.001). Even when only patients without established kidney failure were analyzed, the creatinine clearance rate had prognostic significance (rate ≥ 90 mL/min, mortality 3.2%; rate 89-60 mL/min, mortality 13.9%; P=.02). On Cox regression analysis, which included age, sex, heart failure etiology, left ventricular ejection fraction, diabetes and hypertension, the creatinine clearance rate remained an independent predictor of mortality.

Revue / Journal Title

Revista española de cardiología    ISSN  0300-8932 

Source / Source

2007, vol. 60, n^o12, pp. 1315-1318 [4 page(s) (article)]

Langue / Language

Espagnol

Editeur / Publisher

Elsevier, Barcelone, ESPAGNE  (1947) (Revue)

Localisation / Location

INIST-CNRS, Cote INIST : 13819, 35400016186752.0110