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Titre du document / Document title

The effects of pH on fluoxetine in Japanese medaka (Oryzias latipes) : Acute toxicity in fish larvae and bioaccumulation in juvenile fish

Auteur(s) / Author(s)

NAKAMURA Yuki (1) ; YAMAMOTO Hiroshi (1) ; SEKIZAWA Jun (1) ; KONDO Takuya (2) ; HIRAI Narisato (2) ; TATARAZAKO Norihisa (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) University of Tokushima, Department of Mathematical and Natural Sciences, 1-1, Minamijosanjima-cho, Tokushima 770-8502, JAPON
(2) National Institute for Environmental Studies, 16-2, Onogawa, Tsukuba, Ibaraki 305-8506, JAPON

Résumé / Abstract

Recent detection of fluoxetine in the aquatic environment and fish suggests a possibly high accumulation of fluoxetine; however, no report is available on the bioaccumulation of fluoxetine in aquatic organisms. Since bioaccumulation of fluoxetine was probably dependent on pH near the pKa value of 10.1, experiments were conducted approximately at pH 7, 8, and 9. Distribution coefficients between 1-octanol and water (Dow), and those between synthetic membrane vesicles (liposomes) and water (Dlip-wat) were determined at pH 7, 8, and 9. The Dow and Dlip-wat values increased significantly with increasing pH. Acute toxicity tests were performed using Japanese medaka (Oryzias latipes) prior to the bioaccumulation test, and 96-h LC50 values were 5.5, 1.3, and 0.20 mg 1-1 at pH 7, 8, and 9, respectively. In the bioaccumulation test, concentrations of fluoxetine and its major metabolite, norfluoxetine, in the fish body and liver were measured. The bioconcentration factors (BCF) of fluoxetine for Japanese medaka were 8.8, 3.0 × 10, and 2.6 × 102 in the body and 3.3 × 102, 5.8 × 102, and 3.1 x 103 in the liver at pH 7, 8, and 9, respectively. The BCF values were lower at pH 7 and higher at pH 9 mainly because of the increase in nonionized species with significantly higher hydrophobicity than the ionized species at pH values closer to pKa. A similar trend was obtained for the concentration of norfluoxetine in the fish but the pseudo-BCF values (the ratio of the norfluoxetine concentration in the fish and the fluoxetine concentration in test water) were higher than the BCF value of fluoxetine at all pH conditions.

Revue / Journal Title

Chemosphere    ISSN  0045-6535   CODEN CMSHAF 

Source / Source

2008, vol. 70, no5, pp. 865-873 [9 page(s) (article)] (1/2 p.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1972) (Revue)

Mots-clés anglais / English Keywords

Aquatic environment

;

Developmental stage

;

Vertebrata

;

Oryzias latipes

;

Fluoxetine

;

Freshwater environment

;

Ecotoxicology

;

Young animal

;

Biological accumulation

;

Larva

;

Pisces

;

Toxicity

;

Acute

;

pH

;

Mots-clés français / French Keywords

Cyprinodontidae

;

Milieu aquatique

;

Stade développement

;

Vertebrata

;

Facteur bioconcentration

;

Oryzias latipes

;

Fluoxétine

;

Milieu eau douce

;

Ecotoxicologie

;

Animal jeune

;

Accumulation biologique

;

Larve

;

Pisces

;

Toxicité

;

Aigu

;

pH

;

Mots-clés espagnols / Spanish Keywords

Medio acuático

;

Grado desarrollo

;

Vertebrata

;

Oryzias latipes

;

Fluoxetina

;

Medio agua dulce

;

Ecotoxicología

;

Animal joven

;

Acumulación biológica

;

Larva

;

Pisces

;

Toxicidad

;

Agudo

;

pH

;

Mots-clés d'auteur / Author Keywords

Fluoxetine

;

Bioconcentration factor

;

Ecotoxicity

;

lonization

;

Localisation / Location

INIST-CNRS, Cote INIST : 15565, 35400017457343.0150

Nº notice refdoc (ud4) : 20006987



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