Titre du document / Document title

Ameliorative Effect of Artichoke (Cynara scolymus L.) Extracts on Creatine Monohydrate-induced Renal Dysfunction in Male Rats

Auteur(s) / Author(s)

AHMED Hanaa H. ; MANNAA Fathia ; EL-SAYED Eman M. ;

Résumé / Abstract

The present study aimed to assess the hazards of creatine loading on the renal functions and to evaluate the renoprotective effect of artichoke extracts against creatine-induced nephrotoxicity. Adult Sprague Dawley male rats were orally administered with 300 mg/kg b.wt. of creatine for 4 weeks. As compared to untreated control, this dose of creatine produced significant increase in both of plasma urea and creatinine level, and urinary N-acetyl-β-D-glucosaminidase (NAG) level. Moreover, creatine administration markedly elevated plasma sodium, ammonia and lactate concentrations and significantly reduced plasma potassium level. Plasma aldosterone and corticosterone levels showed significant elevation while plasma testosterone and insulin levels revealed remarkable reduction in creatine-treated group versus the untreated control group. Oral administration of aqueous artichoke leaf or head extract (400 mg/kg b.wt.) along with creatine for 4 weeks caused significant reduction in plasma urea, creatinine and sodium as well as they produced an appreciable decrease in plasma ammonia and lactate with concomitant increase in plasma potassium levels as compared with those given creatine alone. Artichoke head extract could significantly modulate the increase in plasma corticosterone concentration as compared with that of creatine-treated group. In conclusion, long-term creatine ingestion as a nutritional supplement possibly may cause nephron damage and subsequent decline in kidney function. Artichoke leaf or head extracts exhibited renoprotective effect. Noteworthy, head extract expressed more pronounced effect than that of leaf extract. The protective action of artichoke extracts possibly may be due to anticonstrictive properties and the antioxidant activity.

Revue / Journal Title

Deutsche Lebensmittel-Rundschau    ISSN  0012-0413   CODEN DLRUAJ 

Source / Source

2008, vol. 104, n^o1, pp. 29-36 [8 page(s) (article)]

Langue / Language

Anglais
Revue : Allemand

Editeur / Publisher

Behr's Verlag, Hamburg, ALLEMAGNE  (1936) (Revue)

Mots-clés d'auteur / Author Keywords

Creatine ; renal function ; hormones ; artichoke extracts ;

Localisation / Location

INIST-CNRS, Cote INIST : 5541, 35400017454548.0060