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Titre du document / Document title

Leukaemia in young children living in the vicinity of German nuclear power plants

Auteur(s) / Author(s)

KAATSCH Peter (1) ; SPIX Claudia (1) ; SCHULZE-RATH Renate (1) ; SCHMIEDEL Sven (1) ; BLETTNER Maria (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Institute for Medical Biostatistics, Epidemiology and Informatics, German Childhood Cancer Registry, Obere Zahlbacher Strasse 69, 55131 Mainz, ALLEMAGNE

Résumé / Abstract

A case control study was conducted where cases were children younger than 5 years (diseased between 1980 and 2003) registered at the german childhood cancer registry (GCCR). Population-based matched controls (1:3) were selected from the corresponding registrar's office. Residential proximity to the nearest nuclear power plant was determined for each subject individually (with a precision of about 25 m). The report is focused on leukaemia and mainly on cases in the inner 5-km zone around the plants. The study includes 593 leukaemia cases and 1,766 matched controls. All leukaemia combined show a statistically significant trend for 1/distance with a positive regression coefficient of 1.75 [lower 95%-confidence limit (CL): 0.65]; for acute lymphoid leukaemia 1.63 (lower 95%-CL: 0.39), for acute non-lymphocytic leukaemia 1.99 (lower 95%-CL: -0.41). This indicates a negative trend for distance. Cases live closer to nuclear power plants than the randomly selected controls. A categorical analysis shows a statistically significant odds ratio of 2.19 (lower 95%-CL: 1.51) for residential proximity within 5 km compared to residence outside this area. This result is largely attributed to cases in previous studies of the GCCR (especially in the inner zone) as there is clearly some overlap between those studies. The result was not to be expected under current radiation-epidemiological knowledge. Considering that there is no evidence of relevant accidents and that possible confounders could not be identified, the observed positive distance trend remains unexplained.

Revue / Journal Title

International journal of cancer    ISSN  0020-7136   CODEN IJCNAW 

Source / Source

2008, vol. 122, no4, pp. 721-726 [6 page(s) (article)] (26 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley-Blackwell, Hoboken, NJ, ETATS-UNIS  (1966) (Revue)

Mots-clés anglais / English Keywords

Public health

;

Cancer

;

Malignant hemopathy

;

Europe

;

Human

;

Epidemiology

;

Cancerology

;

Register

;

Nuclear power plant

;

Germany

;

Child

;

Leukemia

;

Mots-clés français / French Keywords

Santé publique

;

Cancer

;

Hémopathie maligne

;

Europe

;

Homme

;

Epidémiologie

;

Cancérologie

;

Registre

;

Centrale nucléaire

;

Allemagne

;

Enfant

;

Leucémie

;

Mots-clés espagnols / Spanish Keywords

Salud pública

;

Cáncer

;

Hemopatía maligna

;

Europa

;

Hombre

;

Epidemiología

;

Cancerología

;

Registro

;

Central nuclear

;

Alemania

;

Niño

;

Leucemia

;

Mots-clés d'auteur / Author Keywords

childhood

;

leukaemia

;

nuclear power plants

;

population- based

;

cancer registry

;

Localisation / Location

INIST-CNRS, Cote INIST : 13027, 35400017392102.0020

Nº notice refdoc (ud4) : 19962061



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