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Titre du document / Document title

Effects of Helicobacter pylori Infection on Human Pancreatic Cancer Cell Line

Auteur(s) / Author(s)

TAKAYAMA Satoru (1) ; TAKAHASHI Hiroki (1) ; MATSUO Yoichi (1) ; OKADA Yuji (1) ; MANABE Tadao (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Gastroenterological Surgery, Nagoya City University, Nagoya, JAPON

Résumé / Abstract

Background/Aims: Helicobacter species has been shown to be commonly present in extragastric human organs by polymerase chain reaction (PCR). To date, a few studies have reported that infection by Helicobacter pylori (H. pylori) was a risk factor for pancreatic malignancies, but this was not investigated very well. Therefore, we examined effects of H. pylori infection on human pancreatic cancer cells. Methodology: Interleukin (IL)-8 and vascular endothelial growth factor (VEGF) secretions by human pancreatic cancer cells which were co-cultured with H. pylori, were measured by enzyme-linked immunosorbent assay (ELISA). We then examined whether activities of proliferation factors nuclear factor-KB (NF-KB), activator protein-1 (AP-1), and serum response element (SRE) of human pancreatic cancer cells were increased by H. pylori infection. Furthermore, we examined cytotoxin-associated gene A protein (CagA) secretion into pancreatic cancer cells using Western blotting. Results: IL-8 and VEGF secretion levels and activities of proliferation factors NF-KB, AP-1, and SRE of human pancreatic cells increased by H. pylori infection. Moreover, CagA secretion into pancreatic cancer cells was confirmed by Western blotting. Conclusions: Helicobacter pylori infection of human pancreatic cells may increase malignant potential of pancreatic cells, which seems to involve the same mechanisms as in gastric cancer cells.

Revue / Journal Title

Hepato-gastroenterology    ISSN  0172-6390   CODEN HEGAD4 

Source / Source

2007, vol. 54, no80, pp. 2387-2391 [5 page(s) (article)] (24 ref.)

Langue / Language

Anglais

Editeur / Publisher

H.G.E., Stuttgart, ALLEMAGNE  (1980) (Revue)

Mots-clés anglais / English Keywords

Pancreatic disease

;

Cancer

;

Malignant tumor

;

Digestive diseases

;

Bacteria

;

Spirillales

;

Spirillaceae

;

Vascular endothelium growth factor

;

Protein

;

Transcription factor NFκB

;

Cell line

;

Tumor cell

;

Human

;

Infection

;

Helicobacter pylori

;

Pancreas cancer

;

Mots-clés français / French Keywords

Pathologie du pancréas

;

Cancer

;

Tumeur maligne

;

Pathologie de l'appareil digestif

;

Bactérie

;

Spirillales

;

Spirillaceae

;

Facteur croissance endothélium vasculaire

;

Protéine

;

Facteur transcription NFκB

;

Lignée cellulaire

;

Cellule tumorale

;

Homme

;

Infection

;

Helicobacter pylori

;

Cancer du pancréas

;

Mots-clés espagnols / Spanish Keywords

Páncreas patología

;

Cáncer

;

Tumor maligno

;

Aparato digestivo patología

;

Bacteria

;

Spirillales

;

Spirillaceae

;

Factor crecimiento endotelio vascular

;

Proteína

;

Factor transcripción NFκB

;

Línea celular

;

Célula tumoral

;

Hombre

;

Infección

;

Helicobacter pylori

;

Cáncer del páncreas

;

Mots-clés d'auteur / Author Keywords

Helicobacter pylori

;

Pancreatic cancer

;

Nuclear factor-KB

;

Cytotoxin associated gene A protein

;

Vascular endothelial growth factor

;

Localisation / Location

INIST-CNRS, Cote INIST : 9633, 35400016270663.0450

Nº notice refdoc (ud4) : 19958865



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