Titre du document / Document title

Comparative usefulness of C-reactive protein and erythrocyte sedimentation rate in juvenile rheumatoid arthritis

Auteur(s) / Author(s)

WU J.-F. ^{(1 2)} ; YANG Y.-H. ⁽¹⁾ ; WANG L.-C. ⁽¹⁾ ; LEE J.-H. ⁽¹⁾ ; SHEN E.-Y. ⁽²⁾ ; CHIANG B.-L. ^{(1 3)} ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Pediatrics, National Taiwan University Hospital, Taipei, TAIWAN, PROVINCE DE CHINE
⁽²⁾ Department of Pediatrics, Taipei Medical University-Wan Fang Hospital, Taipei, TAIWAN, PROVINCE DE CHINE
⁽³⁾ Graduate Institute of Clinical Medicine, National Taiwan University, College of Medicine, Taipei, TAIWAN, PROVINCE DE CHINE

Résumé / Abstract

Objective. To compare serial C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels in juvenile rheumatoid arthritis (JRA) patients and investigate their application as diagnostic parameters and prognostic predictive factors. Methods. We carried out retrospective chart review among JRA patients who were followed-up at the National Taiwan University Hospital (NTUH) between 1994 and 2005. Results. Thirty-nine girls and 68 boys were included in this study. At the time of diagnosis, the prevalence of ESR was significantly greater than that of CRP (86.8% vs. 47.2%, p < 0.05). ESR revealed more responsiveness to treatment compared to CRP (SRMs were -0.69 and -0.31, respectively). At the time of diagnosis, high CRP levels (≥ 5mg/dL) correlated with poor therapeutic response, as do positive CRP (> 0.8 mg/dL) and high ESR levels (> 40 mm/ h) after treatment for six months. Overall, initial high CRP levels (≥L 5mg/dL) demonstrated the strongest predictive role of failure of the first remission. Conclusions. For disease diagnosis, ESR can be a better parameter than CRP but a high initial CRP level can strongly predict treatment failure of the first remission.

Revue / Journal Title

Clinical and experimental rheumatology    ISSN  0392-856X 

Source / Source

2007, vol. 25, n^o5, pp. 782-785 [4 page(s) (article)] (20 ref.)

Langue / Language

Anglais

Editeur / Publisher

Clinical and Experimental Rheumatology, Pisa, ITALIE  (1983) (Revue)

Mots-clés anglais / English Keywords

Diseases of the osteoarticular system

;

Inflammatory joint disease

;

Chronic

;

Sedimentation rate

;

C reactive protein

;

Comparative study

;

Juvenile rheumatoid arthritis

;

Mots-clés français / French Keywords

Pathologie du système ostéoarticulaire

;

Rhumatisme inflammatoire

;

Chronique

;

Vitesse sédimentation

;

Protéine C réactive

;

Etude comparative

;

Arthrite chronique juvénile

;

Mots-clés espagnols / Spanish Keywords

Sistema osteoarticular patología

;

Reumatismo inflamatorio

;

Crónico

;

Velocidad sedimentación

;

Proteína reactiva

;

Estudio comparativo

;

Artritis crónica juvenil

;

Mots-clés d'auteur / Author Keywords

Juvenile rheumatoid arthritis

;

C-reactive protein

;

erythrocyte sedimentation rate

;

Localisation / Location

INIST-CNRS, Cote INIST : 20920, 35400016269681.0240