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Titre du document / Document title

Effect of Calophyllolide, a Nonsteroidal Anti-Inflammatory Agent, on Capillary Permeability

Auteur(s) / Author(s)

Saxena R. C. (1) ; Nath R. ; Palit G. ; Nigam S. K. ; Bhargava K. P. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pharmacology and Therapeutics King George's Medical College, Lucknow, India

Résumé / Abstract

Calophyllolide, a nonsteroidal anti-inflammatory agent, was found to be effective in reducing the increased capillary permeability induced in mice by various chemical mediators involved in the inflammatory process viz. histamine (HA), 5-hydroxytryptamine (5-HT) and bradykinin (BK). Pretreatment with Calophyllolide (p. o.) afforded significant protection against induced increase in capillary permeability by HA (PD 50 144.1 mg/kg), 5-HT (PD 50 250.0 mg/kg) and BK (PD 50 133.5 mg/kg). Clinical studies with Calophyllolide in different inflammatory disorders are warranted, in view of its very similar safety margin to oxyphenbutazone (21.4 mg/kg and 25 mg/kg respectively).

Revue / Journal Title

Planta medica    ISSN  1439-0221 

Source / Source

1982, vol. 44, no4, pp. 246-248 [3 page(s) (article)]

Langue / Language

Anglais
Revue : Multilingue

Editeur / Publisher

Thieme, Stuttgart, ALLEMAGNE  (1999) (Revue)

Mots-clés d'auteur / Author Keywords

Calophyllum inophyllum

;

Guttiferae

;

Calophyllolide

;

Capillary Permeability

;

Localisation / Location

35400060008902.0015

Tous droits réservés © Georg Thieme Verlag Stuttgart, New York, 1982
Nº notice refdoc (ud4) : 19932182



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