Titre du document / Document title

Cervical intraepithelial neoplasia grade 3 lesions can regress

Auteur(s) / Author(s)

MUNK Ane Cecilie ^{(1 2)} ; KRUSE Arnold-Jan ^{(1 3)} ; VAN DIERMEN Bianca ⁽¹⁾ ; JANSSEN Emiel A. M. ⁽¹⁾ ; SKALAND Ivar ⁽¹⁾ ; GUDLAUGSSON Einar ⁽¹⁾ ; NILSEN Stein Tore ^{(1 4)} ; BAAK Jan P. A. ^{(1 5 6)} ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Departments of Pathology, Stavanger University Hospital, Stavanger, NORVEGE
⁽²⁾ Departments of Gynecology, Stavanger University Hospital, Stavanger, NORVEGE
⁽³⁾ Academic Medical Center Maastricht, Maastricht, PAYS-BAS
⁽⁴⁾ Institute of Clinical Medicine, University of Bergen, Bergen, NORVEGE
⁽⁵⁾ The Gade Institute, University of Bergen, Bergen, NORVEGE
⁽⁶⁾ Free University, Amsterdam, PAYS-BAS

Résumé / Abstract

Up to 30% of cervical intraepithelial grades 2-3 (CIN2-3) lesions regress, but some believe that "regression" is due to "curative" punch biopsies. If this is true, CIN2-3 in the resection margins of the biopsies would be associated with more frequent "persistent" CIN2-3. If, however, immunology-related regression exists, regression would increase with increasing biopsy-cone interval. In 61 punch biopsies diagnosed as CIN3 at careful review by two independent gynaecological pathologists, CIN3 in the resection margins and duration of the biopsy-cone interval was evaluated in relation to CIN2-3-or-not in the cones (again after independent review by expert pathologists). 10 of 61 (16%) patients with CIN3 showed CIN1 or less in the follow-up cones. CIN3-or-not in the resection margins, size of the lesion in the punch biopsy, and presence or absence of CIN2-3 in the cones were not correlated with regression-or-not. However, the number of cones without CIN2-3 increased with longer biopsy-cone interval, 5% in patients with a punch-cone biopsy interval under 9 weeks and 38%≥9 weeks (p<0.001). These results favour the hypothesis that CIN3 can regress, and do not support the "curative punch biopsy" theory.

Revue / Journal Title

APMIS. Acta pathologica, microbiologica et immunologica Scandinavica   ISSN 0903-4641 

Source / Source

2007, vol. 115, n^o12, pp. 1409-1414 [6 page(s) (article)] (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1988) (Revue)

Mots-clés anglais / English Keywords

Uterine cervix diseases ; Female genital diseases ; Premalignant lesion ; Human ; Cervical intraepithelial neoplasia ; Intraepithelial neoplasia ; Woman ; Regression ; Uterine cervix ;

Mots-clés français / French Keywords

Pathologie du col de l'utérus ; Pathologie de l'appareil génital femelle ; Lésion précancéreuse ; Homme ; Néoplasie intraépithéliale col utérus ; Néoplasie intraépithéliale ; Femme ; Régression ; Col utérus ;

Mots-clés espagnols / Spanish Keywords

Cuello útero patología ; Aparato genital hembra patología ; Lesión precancerosa ; Hombre ; Neoplasia intraepitelial cuelo útero ; Neoplasia intraepitelial ; Mujer ; Regresión ; Cuello útero ;

Mots-clés d'auteur / Author Keywords

Cervix ; intraepithelial neoplasia ; HSIL ; regression ;

Localisation / Location

INIST-CNRS, Cote INIST : 948, 35400017432585.0120