Titre du document / Document title
Pre-Exposure Rabies Vaccination Using Purified Chick Embryo Cell Rabies Vaccine Intradermally is Immunogenic and Safe
Auteur(s) / Author(s)
KAMOLTHAM Thavatchai (1) ;
THINYOUNYONG Wirawan (1) ;
PHONGCHAMNAPHAI Phana (1) ;
PHRAISUWAN Phran (1) ;
KHAWPLOD Pakamatz (2) ;
BANZHOFF Angelika (3) ;
MALERCZYK Claudius (3) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Provincial Health Office of Phetch abun, Ministry of Health, Phetchabun, THAILANDE
(2) Queen Saov abha Memorial Institute, Thai Red Cross Society and Department of Medicine, Chulalongkom Hospital, THAILANDE
(3) Novartis Vaccines & Diagnostics, Clinical Research and Medical Affairs, Marburg, ALLEMAGNE
Résumé / Abstract
Objective To demonstrate the safety and immunogenicity of intradermal rabies pre-exposure prophylaxis with purified chick embryo cell vaccine (PCECV) in schoolchildren age 5 to 8 years in Thailand. Study design In a randomized, open-label, phase II clinical trial, 2 or 3 intradermal doses of 0.1 mL PCECV (Rabipur®) were administered to 703 schoolchildren on days 0 and 28 or on days 0, 7, and 28. In 206 children, 2 simulated post-exposure booster doses were given 1 year after the primary vaccination series. Rabies virus- neutralizing antibody (RVNA) titers were determined by the rapid fluorescent focus inhibition test. Results In school-age children in Thailand, a pre-exposure immunization regimen of 3 intradermal doses of PCECV produced adequate immune responses. After primary vaccination, all subjects developed RVNA titers ≥0.5 lU/mL and demonstrated a rapid increase in RVNA titer after 2 simulated post-exposure booster immunizations 1 year after the primary vaccination series. No serious adverse drug reactions occurred. Conclusions Rabies pre-exposure immunization with PCECV is safe and immunogenic, and its implementation could save the lives of many children in rabies-endemic areas.
Revue / Journal Title
The Journal of pediatrics
ISSN
0022-3476
CODEN JOPDAB
Source / Source
2007, vol. 151, n
o2, pp. 173-177 [5 page(s) (article)] (21 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Maryland Heights, MO, ETATS-UNIS
(1932)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 2061, 35400016216575.0160
Nº notice refdoc (ud4) : 19867126
