Titre du document / Document title

Antihypertensive effect of the combination of fosinopril and HCTZ is resistant to interference by nonsteroidal antiinflammatory drugs

Auteur(s) / Author(s)

THAKUR V. ⁽¹⁾ ; COOK M. E. ⁽¹⁾ ; WALLIN J. D. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Section of Nephrology, Department of Medicine, Louisiana State University Medical Center, New Orleans, Louisiana, ETATS-UNIS

Résumé / Abstract

Nonsteroidal antiinflammatory drugs (NSAID) are frequently reported to interfere with the blood pressure lowering actions of various antihypertensive medications. We studied 17 women with arthritis and hypertension who were receiving fosinopril and HCTZ, and administered sequentially in random order ibuprofen, sulindac, and nabumetone for 1 month each, with an intervening 2-week washout period between each treatment period. During the washout period, subjects received acetaminophen. Blood pressure at the end of 2 weeks of acetaminophen was compared with blood pressure after 1 month of treatment with each of the NSAID. Mean blood pressure was unchanged before and after all NSAID: 108 ± 7 v 107 ± 9 for nabumetone, 108 ± 9 v 108 ± 9 for sulindac, and 108 ± 8 v 107 ± 9 for ibuprofen. The 24-h urinary sodium excretion was not significantly different. We conclude that the three NSAID did not neutralize the antihypertensive effect of the combination of fosinopril and HCTZ, and hence the blood pressure lowering action of the combination may not be prostaglandin dependent.

Revue / Journal Title

American journal of hypertension   ISSN 0895-7061 

Source / Source

1999, vol. 12 (1), n^o9, pp. 925-928 (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1988) (Revue)

Mots-clés anglais / English Keywords

Hypertension ; Fosinopril ; Peptidyl-dipeptidase A ; Enzyme inhibitor ; Hydrochlorothiazide ; Diuretic ; Nabumetone ; Sulindac ; Ibuprofen ; Arterial pressure ; Chemotherapy ; Treatment ; Drug interaction ; Human ; Antihypertensive agent ; Thiazide ; Non steroidal antiinflammatory agent ; Peptidyl-dipeptidases ; Peptidases ; Hydrolases ; Enzyme ; Cardiovascular disease ;

Mots-clés français / French Keywords

Hypertension artérielle ; Fosinopril ; Peptidyl-dipeptidase A ; Inhibiteur enzyme ; Hydrochlorothiazide ; Diurétique ; Nabumétone ; Sulindac ; Ibuprofène ; Pression artérielle ; Chimiothérapie ; Traitement ; Interaction médicamenteuse ; Homme ; Antihypertenseur ; Thiazide ; Antiinflammatoire non stéroïde ; Angiotensin converting enzyme ; Peptidyl-dipeptidases ; Peptidases ; Hydrolases ; Enzyme ; Appareil circulatoire pathologie ;

Mots-clés espagnols / Spanish Keywords

Hipertensión arterial ; Fosinopril ; Peptidyl-dipeptidase A ; Inhibidor enzima ; Hidroclorotiazida ; Diurético ; Nabumetona ; Sulindaco ; Ibuprofeno ; Presión arterial ; Quimioterapia ; Tratamiento ; Interacción medicamentosa ; Hombre ; Antihipertensivo ; Tiazida ; Antiinflamatorio no esteroide ; Peptidyl-dipeptidases ; Peptidases ; Hydrolases ; Enzima ; Aparato circulatorio patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 21579, 35400008033343.0120