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Titre du document / Document title

Treatment of acute relapses in multiple sclerosis at home with oral dexamethasone : a pilot study

Auteur(s) / Author(s)

DE KEYSER J. (1) ; ZWANIKKEN C. (1) ; ZORGDRAGER A. (1) ; OENEMA D. (1) ; BOON M. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Neurology, Academisch Ziekenhuis Groningen, Groningen, PAYS-BAS

Résumé / Abstract

The objective of this study was to investigate the feasibility of treating relapses of multiple sclerosis (MS) at home with oral dexamethasone. Twenty-five out of 28 consecutive patients with MS who presented with a relapse of less than 2 weeks' duration were treated on an open basis with oral dexamethasone 16 mg per day (four divided doses) for 5 consecutive days. After one week, the expanded disability status scale (EDSS) had improved by one or more grades in 88% (22 patients) and after 4 weeks in 92% (23 patients). Treatment was well tolerated. We conclude that a course of oral dexamethasone 16 mg per day shortens the duration of an exacerbation in MS in a similar way as seen after high dose i.v. methylprednisolone. Although a randomized study is needed to test this treatment regimen against i.v. high dose corticosteroids, oral dexamethasone can be used in situations when i.v. therapy is difficult to apply.

Revue / Journal Title

Journal of clinical neuroscience    ISSN  0967-5868 

Source / Source

Congrès
Australian Association of Neurologists, Annual Scientific Meeting (24/05/1999)
1999, vol. 6, no 5, pp. 428-450 (14 ref.), pp. 382-384

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Oxford, ROYAUME-UNI  (1994) (Revue)

Mots-clés anglais / English Keywords

Multiple sclerosis

;

Dexamethasone

;

Oral administration

;

Ambulatory

;

Relapse

;

Chemotherapy

;

Treatment

;

Human

;

Previous study

;

Corticosteroid

;

Nervous system diseases

;

Central nervous system disease

;

Inflammatory disease

;

Route of administration

;

Mots-clés français / French Keywords

Sclérose en plaque

;

Dexaméthasone

;

Voie orale

;

Ambulatoire

;

Récidive

;

Chimiothérapie

;

Traitement

;

Homme

;

Etude préalable

;

Corticostéroïde

;

Système nerveux pathologie

;

Système nerveux central pathologie

;

Maladie inflammatoire

;

Voie administration

;

Mots-clés espagnols / Spanish Keywords

Esclerosis en placa

;

Dexametasona

;

Vía oral

;

Ambulatorio

;

Recaida

;

Quimioterapia

;

Tratamiento

;

Hombre

;

Estudio previo

;

Corticoesteroide

;

Sistema nervioso patología

;

Sistema nervosio central patología

;

Enfermedad inflamatoria

;

Vía administración

;

Localisation / Location

INIST-CNRS, Cote INIST : 26447, 35400008977838.0060

Nº notice refdoc (ud4) : 1970184



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