Titre du document / Document title
Therapy with hyperbaric oxygen and cefazolin for experimental osteomyelitis due to Staphylococcus aureus in rats
Auteur(s) / Author(s)
MENDEL V. (1) ;
REICHERT B. (1) ;
SIMANOWSKI H.-J. (1) ;
SCHOLZ H.-C. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of General Surgery, Diakonissenhospital, Marienhötzungsweg 2, 24939 Flensburg, ALLEMAGNE
Résumé / Abstract
Hyperbaric oxygen (HBO
2) is used as adjunctive therapy for chronic osteomyelitis, yet its efficacy remains controversial. A recently developed rat model for osteomyelitis due to Staphylococcus aureus was used to compare the results of treatment with HBO
2, cefazolin, a combination of both, or no treatment. For the induction of tibial osteomyelitis, S. aureus was inoculated into the medullary cavity. Arachidonic acid was used as the sclerosing agent. With that procedure, an infection rate of 96% was attained. For long-term antibiotic treatment, a port system was developed and implanted. Hyperbaric treatment alone reduced the colony-forming units (CFU) from 2.9 × 10
6 to 6.2 × 10
5.g
-1 of tibial bone. The effect on the infection was more pronounced with antibiotic therapy alone; 10.5 × 10
4 CFU per g of tibial bone were measured. However, changes were most marked using a 4-wk combination therapy consisting of HBO
2 and an antibiotic agent. The colony count was 2.7 × 10
3 CFU. Each of the treatment modalities resulted in a significant therapeutic effect. The results not only demonstrated the effectiveness of HBO
2 in the treatment of osteomyelitis, but revealed a potential additive effect with the combination of HBO
2 and an antibiotic.
Revue / Journal Title
Undersea & hyperbaric medicine
ISSN
1066-2936
CODEN UHMEE7
Source / Source
1999, vol. 26, n
o3, pp. 169-174 (26 ref.)
Langue / Language
Anglais
Editeur / Publisher
Undersea and Hyperbaric Medical Society, Kensington, MD, ETATS-UNIS
(1993)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 16738, 35400008996531.0060
Nº notice refdoc (ud4) : 1927551
