Titre du document / Document title

Improvement by N-acetylcysteine of acute respiratory distress syndrome through increasing intracellular glutathione, and extracellular thiol molecules and anti-oxidant power : evidence for underlying toxicological mechanisms

Auteur(s) / Author(s)

MOHAMMAD SADEGH SOLTAN-SHARIFI ⁽¹⁾ ; MOJTAHEDZADEH Mojtaba ⁽¹⁾ ; NAJAFI Atabak ⁽²⁾ ; MOHAMMAD REZA KHAJAVI ⁽²⁾ ; MOHAMMAD REZA ROUINI ⁽¹⁾ ; MORADI Mandana ⁽¹⁾ ; MOHAMMADIRAD Azadeh ⁽¹⁾ ; ABDOLLAHI Mohammad ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, IRAN, REPUBLIQUE ISLAMIQUE D'
⁽²⁾ School of Medicine, Tehran University of Medical Sciences, Tehran, IRAN, REPUBLIQUE ISLAMIQUE D'

Résumé / Abstract

In acute respiratory distress syndrome (ARDS), there is extensive overproduction of free radicals to the extent that endogenous anti-oxidants are overwhelmed, permitting oxidative cell damage. The present study examined the benefit of the anti-oxidant compound N-acetylcysteine (NAC) in the management of ARDS by measuring patient's intracellular glutathione (inside red blood cells) and extracellular (plasma) anti-oxidant defense biomarkers and outcome. Twenty-seven ARDS patients were recruited from the intensive care unit of a teaching Hospital and randomly divided into two groups. Both groups were managed similarly by regular treatments but 17 patients received NAC 150mg/kg at the first day that followed by 50 mg/kg/day for three days and 10 patients did not receive NAC. Treatment by NAC increased extracellular total anti-oxidant power and total thiol molecules and also improved intracellular glutathione and the outcome of the patients. In conclusion, patients with ARDS are in a deficient oxidant-anti-oxidant balance that can get a significant benefit if supplemented with NAC.

Revue / Journal Title

Human & experimental toxicology   ISSN 0960-3271 

Source / Source

2007, vol. 26, n^o9, pp. 697-703 [7 page(s) (article)] (44 ref.)

Langue / Language

Anglais

Editeur / Publisher

Arnold, London, ROYAUME-UNI  (1990) (Revue)

Mots-clés anglais / English Keywords

Lung disease ; Respiratory disease ; Infection ; Viral disease ; Pharmacotherapy ; Human ; Mucolytic ; Oxidative stress ; Mechanism of action ; Treatment ; Thiol ; Extracellular ; Respiratory distress ; Biological marker ; Glutathione ; Intracellular ; Severe acute respiratory syndrome ; Acute ; Antioxidant ; Acetylcysteine ;

Mots-clés français / French Keywords

Pathologie des poumons ; Pathologie de l'appareil respiratoire ; Infection ; Virose ; Pharmacothérapie ; Homme ; Mucolytique ; Stress oxydatif ; Mécanisme action ; Traitement ; Thiol ; Extracellulaire ; Détresse respiratoire ; Marqueur biologique ; Glutathion ; Intracellulaire ; Syndrome respiratoire aigu sévère ; Aigu ; Antioxydant ; Acétylcystéine ;

Mots-clés espagnols / Spanish Keywords

Pulmón patología ; Aparato respiratorio patología ; Infección ; Virosis ; Farmacoterapia ; Hombre ; Mucolítico ; Estrés oxidativo ; Mecanismo acción ; Tratamiento ; Tiol ; Extracelular ; Trastorno respiratorio ; Marcador biológico ; Glutatión ; Intracelular ; Síndrome respiratorio agudo severo ; Agudo ; Antioxidante ; Acetilcisteína ;

Mots-clés d'auteur / Author Keywords

ARDS ; glutathione ; N-acetylcysteine ; oxidative stress ;

Localisation / Location

INIST-CNRS, Cote INIST : 19290, 35400016171911.0030