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Titre du document / Document title

Toxicogenomic response to chlorination includes induction of major virulence genes in Staphylococcus aureus

Auteur(s) / Author(s)

MATTHEW WOOK CHANG (1) ; TOGHROL Freshteh (2) ; BENTLEY William E. (3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, SINGAPOUR
(2) Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742, ETATS-UNIS
(3) Microarray Research Laboratory, Biological and Economic Analysis Division, Office of Pesticide Programs, U. S. Environmental Protection Agency, Fort Meade, Maryland 20755, ETATS-UNIS

Résumé / Abstract

Despite the widespread use of chlorination for microbial control in aqueous environments, cellular response mechanisms of human pathogens, such as Staphylococcus aureus, against chlorination remain unknown. In this work, genome-wide transcriptional analysis was performed to elucidate cellular response of S. aureusto hypochlorous acid, an active antimicrobial product of chlorination in aqueous solution. Our results suggest that hypochlorous acid repressed transcription of genes involved in cell wall synthesis, membrane transport, protein synthesis, and primary metabolism, while amino acid synthesis genes were induced. Furthermore, hypochlorous acid induced transcription of genes encoding major virulence factors of S. aureus, such as exotoxins, hemolysins, leukocidins, coagulases, and surface adhesion proteins, which all play essential roles in staphylococcal virulence. This work implies that chlorination may stimulate production of virulence factors, which provides new insight into host-pathogen interactions and effects of chlorine application for microbial control.

Revue / Journal Title

Environmental science & technology    ISSN  0013-936X   CODEN ESTHAG 

Source / Source

2007, vol. 41, no21, pp. 7570-7575 [6 page(s) (article)] (37 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Chemical Society, Washington, DC, ETATS-UNIS  (1967) (Revue)

Mots-clés anglais / English Keywords

Bacteria

;

Micrococcales

;

Micrococcaceae

;

Gene expression

;

Biological activity

;

Hypochlorous acid

;

Chlorine

;

Disinfecting agent

;

Sensitivity resistance

;

Staphylococcus aureus

;

Mots-clés français / French Keywords

Bactérie

;

Micrococcales

;

Micrococcaceae

;

Expression génique

;

Activité biologique

;

Acide hypochloreux

;

Chlore

;

Désinfectant

;

Sensibilité résistance

;

Staphylococcus aureus

;

Mots-clés espagnols / Spanish Keywords

Bacteria

;

Micrococcales

;

Micrococcaceae

;

Expresión genética

;

Actividad biológica

;

Hipocloroso ácido

;

Cloro

;

Desinfectante

;

Sensibilidad resistencia

;

Staphylococcus aureus

;

Localisation / Location

INIST-CNRS, Cote INIST : 13615, 35400017347858.0550

Nº notice refdoc (ud4) : 19219794



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