Titre du document / Document title
The comparative effects of famciclovir and valacyclovir on herpes simplex virus type 1 infection, latency, and reactivation in mice
Auteur(s) / Author(s)
LEBLANC R. A.
(1) ;
PESNICAK L.
(1) ;
GODLESKI M.
(1) ;
STRAUS S. E.
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Medical Virology Section, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, Maryland, ETATS-UNIS
Résumé / Abstract
Infections by herpes simplex virus (HSV) cannot yet be eliminated, but the severity of the disease can be reduced. Two newer drugs with established efficacy for such infections, famciclovir and valacyclovir, were tested in a mouse eye model of HSV infection. Both drugs significantly reduced mortality and titers of virus shed from the eyes of mice infected with an otherwise lethal dose of HSV type 1 (HSV-I). Similar titers of HSV-1 were found in the eyes, ganglia, and brains of treated animals. Although valacyclovir reduced the latent viral DNA load better in these studies than did famciclovir, rates of reactivation by explantation and UV exposure were the same. Thus, in this study, famciclovir and valacyclovir were equally effective in limiting the virulence and spread of HSV-1, despite their biochemical and pharmacologic differences.
Revue / Journal Title
The Journal of infectious diseases
ISSN 0022-1899
CODEN JIDIAQ
Source / Source
1999, vol. 180, n
o3, pp. 594-599 (29 ref.)
Langue / Language
Anglais
Editeur / Publisher
University of Chicago Press, Chicago, IL, ETATS-UNIS
(1904)
(Revue)
Mots-clés anglais / English Keywords
Herpesvirus hominis 1 ;
Mouse ;
Animal model ;
Viral disease ;
Treatment ;
Chemotherapy ;
Antiviral ;
Treatment efficiency ;
Quantitative analysis ;
Viral load ;
DNA ;
Comparative study ;
Famciclovir ;
Valaciclovir ;
Purine nucleoside ;
Biological activity ;
Alphaherpesvirinae ;
Herpesviridae ;
Virus ;
Rodentia ;
Mammalia ;
Vertebrata ;
Infection ;
Eye disease ;
Mots-clés français / French Keywords
Herpesvirus hominis 1 ;
Souris ;
Modèle animal ;
Virose ;
Traitement ;
Chimiothérapie ;
Antiviral ;
Efficacité traitement ;
Analyse quantitative ;
Charge virale ;
DNA ;
Etude comparative ;
Famciclovir ;
Valaciclovir ;
Purine nucléoside ;
Activité biologique ;
Nucléoside analogue ;
Alphaherpesvirinae ;
Herpesviridae ;
Virus ;
Rodentia ;
Mammalia ;
Vertebrata ;
Infection ;
Oeil pathologie ;
Mots-clés espagnols / Spanish Keywords
Herpesvirus hominis 1 ;
Ratón ;
Modelo animal ;
Virosis ;
Tratamiento ;
Quimioterapia ;
Antiviral ;
Eficacia tratamiento ;
Análisis cuantitativo ;
Carga vírica ;
DNA ;
Estudio comparativo ;
Famciclovir ;
Valaciclovir ;
Purina nucleósido ;
Actividad biológica ;
Alphaherpesvirinae ;
Herpesviridae ;
Virus ;
Rodentia ;
Mammalia ;
Vertebrata ;
Infección ;
Ojo patología ;
Localisation / Location
INIST-CNRS, Cote INIST : 2052, 35400008950009.0030
Nº notice refdoc (ud4) : 1916442
