Titre du document / Document title
Metaloproteasas, remodelado vascular y síndromes aterotrombóticos = Metalloproteases, vascular remodeling and atherothrombotic syndromes
Auteur(s) / Author(s)RODRIGUEZ José A.
PARAMO José A.
Résumé / Abstract
Defects in the synthesis and breakdown of the extracellular matrix (ECM) are now seen as key processes in the development of atherosclerosis and its thrombotic complications. Correlations have been observed between circulating levels of ECM biomarkers and the clinical manifestations of and risk factors for atherosclerosis. Several matrix metalloproteinases (MMPs), endopeptidases that can degrade the ECM, such as MMP-9 and MMP-10, play important roles in the pathophysiology of atherothrombosis and contribute to the expansion of abdominal aortic aneurysms. Moreover, they may also be useful biomarkers of atherosclerotic risk and serve as predictors of coronary and cerebrovascular disease recurrence. Although at present the effect of tissue inhibitors of MMPs (TIMPs) on cardiovascular disease prognosis is still uncertain, the ECM could be a promising therapeutic target in atherothrombotic disease, and several MMP inhibitors are currently undergoing clinical trials.
Revue / Journal TitleRevista española de cardiología
Source / Source
2007, vol. 60, no
9, pp. 959-967 [9 page(s) (article)]
Langue / Language
Editeur / Publisher
Elsevier, Barcelone, ESPAGNE
Localisation / Location
INIST-CNRS, Cote INIST : 13819, 35400016094006.0070
Nº notice refdoc (ud4) : 19149839