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Titre du document / Document title

Ovarian clear cell carcinoma associated with endometriosis : a case report with immunohistochemical study

Auteur(s) / Author(s)

MURTA E. F. C. ; NOMELINI R. S. ; FERREIRA F. A. ; LIMA M. A. ;

Résumé / Abstract

Endometriosis is a frequent benign gynecological disease; nonetheless, it can demonstrate some aspects that resemble malignant disease. Malignant transformation of endometriosis occurs mainly in the ovary. A rare case of transition between typical endometriosis and clear cell carcinoma with immunohistochemical study is presented. The patient, a 30-year-old Caucasian woman (para 0), was diagnosed with endometriosis ten years before. Six months later she developed a left cystic ovarian tumor (58 cm3) that persisted after two ultrasounds in a four-month period. Tumor markers were normal (CA125, CA 15.3, CA 19.9, alpha-fetoprotein, carcinoembrionary antigen Al). There was no ascites. The left ovarian mass was removed by laparotomy and endometriosis in continuity with carcinoma positive for cytokeratin 7 and estrogen receptor was revealed. CD10 was positive in the stromal cells of the endometriosis. Clear cell carcinoma grade 3 was diagnosed. In conclusion, although a rare event, the association of typical endometriosis and clear cell carcinoma of the ovary should be kept in mind, mainly in patients with a persistent ovarian cyst.

Revue / Journal Title

European journal of gynaecological oncology    ISSN  0392-2936 

Source / Source

2007, vol. 28, no5, pp. 403-405 [3 page(s) (article)]

Langue / Language

Anglais

Editeur / Publisher

I.R.O.G Canada, Montréal, QC, CANADA  (1980) (Revue)

Mots-clés d'auteur / Author Keywords

Ovary

;

Clear cell carcinoma

;

Endometriosis

;

Immunohistochemical study

;

Localisation / Location

INIST-CNRS, Cote INIST : 19792, 35400016090400.0120

Nº notice refdoc (ud4) : 19128701



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