Titre du document / Document title

Preventing relapse of major depression during interferon-α therapy for hepatitis C-A pilot study

Auteur(s) / Author(s)

GLEASON Ondria C. ⁽¹⁾ ; FUCCI John C. ⁽²⁾ ; YATES William R. ⁽¹⁾ ; PHILIPSEN Michelle A. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Psychiatry, The University of Oklahoma College of Medicine, Tulsa, 4502 East 41st Street, Tulsa, Oklahoma 74135, ETATS-UNIS
⁽²⁾ Gastroenterology, St. John Health System, 1004 E. Bryan, Sapulpa, Oklahoma 74066, ETATS-UNIS

Résumé / Abstract

Depression is common in hepatitis C, exacerbated by interferon, and is a major reason for discontinuing interferon therapy. We aimed to determine (1) whether patients with a history of major depression could complete a course of peginterferon α-2a and ribavirin if pretreated with escitalopram and (2) the relapse rate of depression during the course of therapy in these subjects. Ten patients were enrolled in the study and treated with escitalopram. The Hamilton Depression Rating Scale (Ham-D) and other psychiatric scales were administered throughout the study. There were no statistically significant increases in mean Ham-D scores. No subjects were discontinued from the study due to depression relapse. Nine of 10 subjects maintained remission of depression throughout the study. We conclude that pretreatment with escitalopram in subjects with major depressive disorder in remission may prevent recurrence of major depression during a course of interferon and ribavirin therapy for hepatitis C.

Revue / Journal Title

Digestive diseases and sciences   ISSN 0163-2116   CODEN DDSCDJ 

Source / Source

2007, vol. 52, n^o10, pp. 2557-2563 [7 page(s) (article)] (27 ref.)

Langue / Language

Anglais

Editeur / Publisher

Springer, Heidelberg, ALLEMAGNE  (1979) (Revue)

Mots-clés anglais / English Keywords

Neurotransmitter ; Selective serotonin reuptake inhibitor ; Serotonin ; Reuptake inhibitor ; Hepatic disease ; Digestive diseases ; Mood disorder ; Infection ; Viral disease ; Antidepressant agent ; Psychotropic ; Prevention ; Viral hepatitis C ; Viral hepatitis A ; Treatment ; Alpha interferon ; Relapse ; Escitalopram ; Depression ;

Mots-clés français / French Keywords

Neurotransmetteur ; Inhibiteur sélectif recapture sérotonine ; Sérotonine ; Inhibiteur recapture ; Foie pathologie ; Appareil digestif pathologie ; Trouble humeur ; Infection ; Virose ; Antidépresseur ; Psychotrope ; Prévention ; Hépatite virale C ; Hépatite virale A ; Traitement ; Interféron alpha ; Récidive ; Escitalopram ; Etat dépressif ;

Mots-clés espagnols / Spanish Keywords

Neurotransmisor ; Inhibidor selectivo recaptura serotonin ; Serotonina ; Inhibidor recaptura ; Hígado patología ; Aparato digestivo patología ; Trastorno humor ; Infección ; Virosis ; Antidepresor ; Psicotropo ; Prevención ; Hepatitis virica C ; Hepatitis vírica A ; Tratamiento ; Interferón alfa ; Recaida ; Escitalopram ; Estado depresivo ;

Mots-clés d'auteur / Author Keywords

Depression ; Hepatitis CI ; Interferon ; Prevention ; Escitalopram ;

Localisation / Location

INIST-CNRS, Cote INIST : 5060, 35400016089196.0150