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Titre du document / Document title

Pedophilia is linked to reduced activation in hypothalamus and lateral prefrontal cortex during visual erotic stimulation

Auteur(s) / Author(s)

WALTER Martin (1) ; WITZEL Joachim (2) ; WIEBKING Christine (1) ; GUBKA Udo (2) ; ROTTE Michael (3) ; SCHILTZ Kolja (1) ; BERMPOHL Felix (4) ; TEMPELMANN Claus (3) ; BOGERTS Bernhard (1) ; JOCHEN HEINZE Hans (3) ; NORTHOFF Georg (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Psychiatry, Otto-von-Guericke University of Magdeburg, Magdeburg, ALLEMAGNE
(2) State Hospital for Forensic Psychiatry of Saxonia Anhaltina, Uchtspringe, ALLEMAGNE
(3) Department of Neurology II, Otto-von-Guericke University of Magdeburg, Magdeburg, ALLEMAGNE
(4) Department of Psychiatry and Psychotherapy Charité Medical School, University Medicine Berlin, Berlin, ALLEMAGNE

Résumé / Abstract

Background: Although pedophilia is of high public concern, little is known about underlying neural mechanisms. Although pedophilic patients are sexually attracted to prepubescent children, they show no sexual interest toward adults. This study aimed to investigate the neural correlates of deficits of sexual and emotional arousal in pedophiles. Methods: Thirteen pedophilic patients and 14 healthy control subjects were tested for differential neural activity during visual stimulation with emotional and erotic pictures with functional magnetic resonance imaging. Results: Regions showing differential activations during the erotic condition comprised the hypothalamus, the periaqueductal gray, and dorsolateral prefrontal cortex, the latter correlating with a clinical measure. Alterations of emotional processing concerned the amygdalahippocampus and dorsomedial prefrontal cortex. Conclusions: Hypothesized regions relevant for processing of erotic stimuli in healthy individuals showed reduced activations during visual erotic stimulation in pedophilic patients. This suggests an impaired recruitment of key structures that might contribute to an altered sexual interest of these patients toward adults.

Revue / Journal Title

Biological psychiatry    ISSN  0006-3223   CODEN BIPCBF 

Source / Source

2007, vol. 62, no6, pp. 698-701 [4 page(s) (article)] (1/2 p.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1969) (Revue)

Mots-clés anglais / English Keywords

Social behavior disorder

;

Medical imagery

;

Visual pathway

;

Central nervous system

;

Encephalon

;

Sex offense

;

Sexual behavior disorder

;

Dorsolateral cortex

;

Periaqueductal gray matter

;

Functional imaging

;

Nuclear magnetic resonance imaging

;

Stimulation

;

Eroticism

;

Visual cortex

;

Prefrontal cortex

;

Lateral hypothalamus

;

Activation

;

Pedophilia

;

Mots-clés français / French Keywords

Trouble comportement social

;

Imagerie médicale

;

Voie visuelle

;

Système nerveux central

;

Encéphale

;

Délinquance sexuelle

;

Trouble comportement sexuel

;

Cortex dorsolatéral

;

Substance grise périaqueducale

;

Imagerie fonctionnelle

;

Imagerie RMN

;

Stimulation

;

Erotisme

;

Cortex visuel

;

Cortex préfrontal

;

Hypothalamus latéral

;

Activation

;

Pédophilie

;

Mots-clés espagnols / Spanish Keywords

Trastorno comportamiento social

;

Imaginería médica

;

Vía visual

;

Sistema nervioso central

;

Encéfalo

;

Crimen sexual

;

Trastorno conducta sexual

;

Corteza dorsolateral

;

Substancia gris periacueductal

;

Imaginería funcional

;

Imaginería RMN

;

Estimulación

;

Erotismo

;

Corteza visual

;

Corteza prefrontal

;

Hipotálamo lateral

;

Activación

;

Pedofilia

;

Mots-clés d'auteur / Author Keywords

Dorsolateral prefrontal cortex

;

fMRI

;

hypothalamus

;

neural mechanism

;

pedophilia

;

periaqueductal gray

;

Localisation / Location

INIST-CNRS, Cote INIST : 11378, 35400016246473.0200

Nº notice refdoc (ud4) : 19066064



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